Interferon Lamda 4, clone 4G1 | EMD Millipore MABF227 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Interferon Lamda 4, clone 4G1

catalog :

MABF227

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G1

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

citations: 3

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 2 ug/ml western blot; human; 2 ug/ml	Paquin A, Onabajo O, Tang W, Prokunina Olsson L. Comparative Functional Analysis of 12 Mammalian IFN-Î»4 Orthologs. J Interferon Cytokine Res. 2016;36:30-6 pubmed publisher
ELISA; human; 4 ug/ml western blot; human	Onabajo O, Porter Gill P, Paquin A, Rao N, Liu L, Tang W, et al. Expression of Interferon Lambda 4 Is Associated with Reduced Proliferation and Increased Cell Death in Human Hepatic Cells. J Interferon Cytokine Res. 2015;35:888-900 pubmed publisher
	Obajemu A, Rao N, Dilley K, Vargas J, Sheikh F, Donnelly R, et al. IFN-Î»4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling. J Immunol. 2017;199:3808-3820 pubmed publisher

product information

Catalog Number :

MABF227

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Interferon Lamda 4, clone 4G1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

K9M1U5

Host Name :

Mouse

Antigen :

IFNL4

Clone :

4G1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Interferon Lamda 4, clone 4G1

Cross Reactivity :

Human

Background :

Interferon Lambda 4, also known as IFN-lambda-4, and encoded by the gene IFNL4, is an important cytokine that forms part of our innate immunity against viruses. Interferon lambda-4 activates the JAK-STAT signaling pathway and ultimately up regulates several interferon specific stimulated genes. Interferon lambda-4 expression can be stimulated by nucleotide strands particularly ployinosinic-polycytidylic acid (polyI:C) which mimics the double-stranded hepatitis C virus. A genetic variation in the Interferon lambda-4 gene is associated with susceptibility to HCV infection. The mutation of a single base insertion results in gene inactivation resulting in defective immune response to HCV. Interferon lambda-4 signaling operates through Interferon lambda R1 and IL-10R2 receptors and the mutation is associated with defective glycosylation which is required for secretion, thus the amplification of the signal becomes compromised resulting in susceptibility to HCV as well as coronaviruses.

ALT Names :

Interferon lambda-4, IFN-lambda-4

Immunogen :

Linear peptide corresponding to human Interferon Lamda 4.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry, Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt