IKKa (p45) Antibody, clone 881H3 | EMD Millipore MABF222 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IKKa (p45) Antibody, clone 881H3

catalog :

MABF222

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

881H3

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

product information

Catalog Number :

MABF222

Subcategory :

Inflammation & Immunology

Product Name :

Anti-IKKa (p45) Antibody, clone 881H3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O15111

Host Name :

Mouse

Antigen :

CHUK

Clone :

881H3

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2aκ

Product Description :

Anti-IKKa (p45) Antibody, clone 881H3

Cross Reactivity :

Human

Background :

The protein named Inhibitor of nuclear factor kappa-B kinase subunit alpha, or alternatively I-kappa-B kinase alpha, IKK-A, IKK-alpha, IKKa (p45), IkBKA, IkappaB kinase, I-kappa-B kinase 1, IKK1, NF-kappa-B inhibitor kinase alpha, NFKBIKA, or transcription factor 16 (TCF-16) and encoded by the human gene CHUK/IKKA/TCF16 is a serine kinase that plays an essential role in the NF-kappa-B signaling pathway. IKKa(p45) acts as part of a complex that phosphorylates inhibitors of the NF-kappa-B. This allows then the polyubiquitination of the inhibitors and their subsequent degradation. Free NF-kappa-B is translocated into the nucleus and performs its gene activation functions governing everything from the immune response to growth and cell survival. IKKa(p45) can be found expressed in most tissues and localizes to both the cytoplasm and nucleus depending upon the microenvironment. Defects in IKKa(p45) are associated with a lethal fetal syndrome called by Cocoon syndrome where the fetus has multiple malformations including limbs bound to the trunk and encased under the skin.

ALT Names :

Inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, IKK1, Nuclear factor NF-kappa-B inhibitor kinase alpha, NFKBIKA, Transcription factor 16, TCF-16

Immunogen :

Conjugated linear peptide corresponding to human IKKa (p45).

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry (Paraffin), Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt