NOD1/CARD4 Antibody, clone 021 | EMD Millipore MABF215 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NOD1/CARD4 Antibody, clone 021

catalog :

MABF215

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

021

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:100; loading ...; fig s1f, s1g immunocytochemistry; mouse; 1:100; loading ...; fig 4g	Lu Y, Zheng Y, Coyaud E, Zhang C, Selvabaskaran A, Yu Y, et al. Palmitoylation of NOD1 and NOD2 is required for bacterial sensing. Science. 2019;366:460-467 pubmed publisher

product information

Catalog Number :

MABF215

Subcategory :

Inflammation & Immunology

Product Name :

Anti-NOD1/CARD4 Antibody, clone 021

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9Y239

Host Name :

Mouse

Antigen :

NOD1

Clone :

021

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-NOD1/CARD4 Antibody, clone 021

Cross Reactivity :

Human

Background :

NOD1/CARD4, also known as Nucleotide-binding oligomerization domain-containing protein 1, or Caspase recruitment domain-containing protein 4, and encoded by the gene NOD1/CARD4, is an important apoptosis mediating protein that enhances caspase-9-mediated apoptosis. NOD1/CARD4 also mediates cellular responsiveness to intracellular bacterial LPS and forms an intracellular sensing system along with another protein called ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. NOD1/CARD4 is a homodimer that is found in the cytoplasm but also associated with the cell membrane in particular cells such as polarized epithelial cells. NOD1/CARD4 is expressed in many tissues including heart, skeletal muscle, and pancreas. As part of the innate immune system NOD1/CARD4 is part of a family of proteins that are responsible for the initial response of an organism to potentially harmful stressors, pathogens or tissue injury, and accordingly plays an essential role in the pathogenesis of many inflammatory processes, including some cardiovascular diseases.

ALT Names :

Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4

Immunogen :

Recombinant protein corresponding to the CARD domain of human NOD1/CARD4.

Package Size :

100 μg

Uses :

Western Blotting, Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt