STING, clone 41 | EMD Millipore MABF213 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

STING, clone 41

catalog :

MABF213

quantity :

100 µL

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

reactivity :

mouse

application :

western blot, flow cytometry

product information

Catalog Number :

MABF213

Subcategory :

Inflammation & Immunology

Product Name :

Anti- STING, clone 41

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q3TBT3

Host Name :

Rat

Antigen :

Tmem173

Clone :

Conjugate :

Purified

Purification Method :

Purified by ion-exchange chromatography

Isotype :

IgMκ

Product Description :

Anti- STING, clone 41

Cross Reactivity :

Mouse

Background :

STING, also known as mSTING, or Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA or Transmembrane protein 173, and encoded by the gene Tmem 173/Eris/Mita/Mpys/Sting, is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferons. STING acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol. Upon binding STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. STING also mediates cell death signaling via the activation of the ERK pathway. STING is found in multiple intracellular locations including the endoplasmic reticulum, plasma cell membrane, mitochondrion outer membrane, and perinuclear regions. STING is expressed in the B-cell lineage both immature and mature B cells but not plasma cells. Mutations in STING cause defects in innate immunity and compromised immune health.

ALT Names :

Stimulator of interferon genes protein, mSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA, Transmembrane protein 173, STING

Immunogen :

Recombinant protein corresponding to the cytoplasmic domain of mouse STING.

Package Size :

100 µL

Uses :

Western Blotting, Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt