CSF1 Antibody, clone 2D10 | EMD Millipore MABF191 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CSF1 Antibody, clone 2D10

catalog :

MABF191

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D10

The same clone is also sold as:

MilliporeSigma: SAB5300318
Novus Biologicals: NBP1-47472
Abnova: MAB10616
Invitrogen: MA5-15599
OriGene: AM06393SU-N
LifeSpan Biosciences: LS-B4135
ProMab: 30008

reactivity :

human

application :

western blot, immunohistochemistry

citations: 2

Reference
Pei Q, Pan J, Zhu H, Ding X, Liu W, Lv Y, et al. Gemcitabine-treated pancreatic cancer cell medium induces the specific CTL antitumor activity by stimulating the maturation of dendritic cells. Int Immunopharmacol. 2014;19:10-6 pubmed publisher
Dam T, Danelishvili L, Wu M, Bermudez L. The fadD2 gene is required for efficient Mycobacterium avium invasion of mucosal epithelial cells. J Infect Dis. 2006;193:1135-42 pubmed

product information

Catalog Number :

MABF191

Subcategory :

Cell Structure

Product Name :

Anti-CSF1 Antibody, clone 2D10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P09603

Host Name :

Mouse

Antigen :

CSF1

Clone :

2D10

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-CSF1 Antibody, clone 2D10

Cross Reactivity :

Human

Background :

Macrophage colony stimulating factor 1 (CSF1,CSF-1, M-CSF, MCSF) or Lanimostim is a cytokine that was first identified as a molecule that plays an important role in the survival, proliferation and differentiation of mononuclear cells such as phagocytes, macrophages and monocytes. Today however we know that CSF1 also serves several other functions in a variety of cell types. CSF1 is essential for normal bone development, osteoclast proliferation, and the resorption of bone. CSF1 is released by osteoclasts upon stimulation by parathyroid hormone. Additionally CSF1 impacts actin and cytoskeleton reorganization which effects cell adhesion and migration, and overstimulation of CSF1 in endothelial cells is linked to the development and progression of atherosclerosis. CSF1 is also highly expressed in the endometrial epithelium of the pregnant uterus and CSF1 is essential for normal embryonic implantation and placental development. CSF1 appears to play an important role in cancer as well; first CSF1 is an anti-tumor agent and increases macrophage expression of anti-tumor activity, but over expression of CSF1 in breast, bone, and several other forms of cancer appears to promote cell invasiveness, proliferation, and tumor survival. Finally, CSF1 as a secreted mature factor promotes the release of proinflammatory cytokines and serves as part of the innate immunity process for inflammation and infection. CSF1 is initially produced as a precursor that is membrane bound but processed and secreted upon stimulation. CSF1 is heavily glycosylated and found both in the ECM as well as surface membranes of cells. CSF1 receptor is found on numerous cell types including macrophages, endothelial cells, and osteoclasts. EMD-Millipore’s Anti-CSF1 mouse monoclonal antibody has been tested in western blot on recombinant protein and in paraffin embedded immunohistochemistry on human placental tissue sections.

ALT Names :

Macrophage colony-stimulating factor 1;CSF-1;M-CSF;MCSF;Lanimostim;Processed macrophage colony-stimulating factor 1

Immunogen :

Purified recombinant fragment of human CSF1 expressed in E. Coli.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.