Ly1.2 (CD5) Antibody, clone 2145 | EMD Millipore MABF19 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Ly1.2 (CD5) Antibody, clone 2145

catalog :

MABF19

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2145

reactivity :

mouse

application :

flow cytometry

citations: 1

Reference
Ren Z, Liu M, Xue Y, Ding Z, Xue L, Zhai S, et al. A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory. Neuropsychopharmacology. 2013;38:778-90 pubmed publisher

product information

Catalog Number :

MABF19

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Ly1.2 (CD5) Antibody, clone 2145

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P13379

Host Name :

Mouse

Antigen :

Ly1.2 (CD5)

Clone :

2145

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Ly1.2 (CD5) Antibody, clone 2145

Cross Reactivity :

Mouse

Background :

CD5 (Ly1.2 in mouse) is a 55 kDa T-lymphocyte single chain transmembrane glycoprotein. It is present on all mature T-lymphocytes, on most thymocytes and on many T-cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T-lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T-cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B cell receptors.

ALT Names :

CD5 molecule;CD5 antigen (p56-62);CD5 antigen;Lymphocyte antigen T1/Leu-1

Immunogen :

Balb/c thymus cells corresponding to B6 Ly-1.1 mouse CD5.

Specificity :

This antibody recognizes Ly1.2 (CD5).

Package Size :

100 µL

Uses :

Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt