KARS Antibody, clone 8G12C1 | EMD Millipore MABF187 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

KARS Antibody, clone 8G12C1

catalog :

MABF187

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8G12C1

The same clone is also sold as:

MilliporeSigma: SAB5300071
Abnova: MAB10375
ProMab: 20238
LifeSpan Biosciences: LS-B4096
OriGene: AM06252SU-N
Invitrogen: MA5-15426

reactivity :

human

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABF187

Subcategory :

Cell Structure

Product Name :

Anti-KARS Antibody, clone 8G12C1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q15046

Host Name :

Mouse

Antigen :

KARS

Clone :

8G12C1

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-KARS Antibody, clone 8G12C1

Cross Reactivity :

Human

Background :

KARS, also known as Lysyl-tRNA synthetase (LysRS), is the enzyme that connects the lysine to its specific tRNA for use in protein translation. KARS is also a powerful inflammatory agent when released into extracellular matrix as one might expect. KARS is largely cytoplasmically localized or localized to internal membranes but isoforms are found in the mitochondria and nucleus as well. KARS became the focus of much attention with HIV-1 as KARS interacted with HIV-1’s GAG protein and facilitated the selective packaging of tRNA3(lys) nucleic acid which acted as the primer for viral reverse transcription and initiation of viral gene expression. There is also at least one genetic disease linked to KARS. It is the cause of Charcot-Marie-Tooth neuropathy a progressive peripheral nervous system disease characterized by progressive weakness and atrophy of the muscles and demyelination and deterioration the peripheral nerves and axons. EMD-Millipore’s Anti-KARS mouse monoclonal antibody has been tested in western blot on recombinant protein and in paraffin embedded immunohistochemistry on human cervical carcinoma tissue sections.

ALT Names :

Lysine-tRNA ligase;Lysyl-tRNA synthetase;LysRS

Immunogen :

Purified recombinant fragment of human KARS expressed in E. Coli.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.