E3 ubiquitin-protein ligase UHRF1 Antibody, clone 7C8 | EMD Millipore MABE945 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

E3 ubiquitin-protein ligase UHRF1 Antibody, clone 7C8

catalog :

MABE945

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7C8

reactivity :

human

application :

western blot, immunocytochemistry, chromatin immunoprecipitation

product information

Catalog Number :

MABE945

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-E3 ubiquitin-protein ligase UHRF1 Antibody, clone 7C8

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q96T88

Host Name :

Mouse

Antigen :

UHRF1

Clone :

7C8

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2bκ

Product Description :

Anti-E3 ubiquitin-protein ligase UHRF1 Antibody, clone 7C8

Cross Reactivity :

Human

Background :

Ubiquitin-like with PHD and ring finger domains 1 (UHRF1), also known as ICBP90 or Np95, is a multifunctional nuclear protein that may be an important mediator of heterochromatin formation which is indicative of gene repression. UHRF1 contains a set and RING-finger-associated domain that detects hemi-methylated cytosine residues leading to the recruitment of DNMT1 to these residues during the S phase. UHRF1 thereby facilitates the transfer of methylation status to newly synthesized DNA molecules. UHRF1 may also interact with histones and HDAC1 via its PHD domain to promote modifications of histone residues which contribute to heterochromatin formation. UHRF1 may also directly modify histone H3 by ubiquitination. In addition, UHRF1 may contribute to the DNA-repair process though associations with PCNA. Several studies have suggested that overexpression of UHRF1 may contribute to the development of many cancers.

ALT Names :

E3 ubiquitin-protein ligase UHRF1, Inverted CCAAT box-binding protein of 90 kDa, Nuclear protein 95, Nuclear zinc finger protein Np95, HuNp95, hNp95, RING finger protein 106, Transcription factor ICBP90, Ubiquitin-like PHD and RING finger domain-containing protein 1, hUHRF1, Ubiquitin-like-containing PHD and RING finger domains protein 1

Immunogen :

Recombinant protein corresponding to human E3 ubiquitin-protein ligase UHRF1.

Package Size :

200 μg

Uses :

Immunocytochemistry, Chromatin Immunoprecipitation (ChIP), Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt