Eri1/Exoribonuclease 1 Antibody, clone 5G8 | EMD Millipore MABE894 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Eri1/Exoribonuclease 1 Antibody, clone 5G8

catalog :

MABE894

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

5G8

reactivity :

mouse

application :

western blot, immunoprecipitation

product information

Catalog Number :

MABE894

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Eri1/Exoribonuclease 1 Antibody, clone 5G8

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q7TMF2

Host Name :

Rat

Antigen :

Eri1

Clone :

5G8

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Eri1/Exoribonuclease 1 Antibody, clone 5G8

Cross Reactivity :

Mouse

Background :

The protein named 3’-5’ exoribonuclease 1 or 3'-5' exonuclease ERI1, Eri-1 homolog, Histone mRNA 3'-end-specific exoribonuclease, Histone mRNA 3'-exonuclease 1, or Protein 3'hExo (HEXO), and encoded by the human gene ERI1/ 3’EXO,/THEX1 is an RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. Eri1 also can degrade 3’ overhangs on short interfering RNAs (siRNAs) suggestion a possible wider role in RNA interference, and finally Eri1 also processes other RNAs, including ribosomal RNAs and Eri1 is part of a pre-mRNA processing complex and can bind ribosomal subunits and assembled ribosomes too. Recent research also has identified Eri1 as a regulator of micro RNA and plays a role in miRNA homeostasis, lymphocyte development and antiviral functions. Eri1 is localized to the cytoplasm and nucleus, as well as, the nucleolus in normal cells.

ALT Names :

3'-5' exoribonuclease 1, 3'-5' exonuclease ERI1, Eri-1 homolog, Histone mRNA 3'-exonuclease 1

Immunogen :

Recombinant protein corresponding to mouse Eri1/Exoribonuclease 1.

Package Size :

100 μg

Uses :

Western Blotting, Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt