26S proteasome regulatory subunit RPN11, clone 7C7.1 | EMD Millipore MABE881 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

26S proteasome regulatory subunit RPN11, clone 7C7.1

catalog :

MABE881

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7C7.1

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

MABE881

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O00487

Host Name :

Mouse

Antigen :

PSMD14

Clone :

7C7.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2bκ

Product Description :

Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1

Cross Reactivity :

Human, Rat

Background :

26S proteasome non-ATPase regulatory subunit 14 is also known as 26S proteasome regulatory subunit RPN11 or 26S proteasome-associated PAD1 homolog 1. This protein is expressed from the PSMD14 gene and is the metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. 26S proteasome non-ATPase regulatory subunit 14 has a role in the response to double-strand breaks (DSBs) by regulating non-homologous end joining (NHEJ) via cleaving 'Lys-63'-linked polyubiquitin, retaining JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. 26S proteasome non-ATPase regulatory subunit 14 is also involved in homologous recombination repair by promoting RAD51 loading. 26S proteasome non-ATPase regulatory subunit 14 is widely expressed, but found in the highest levels in heart and skeletal muscle.

ALT Names :

26S proteasome regulatory subunit RPN11, 26S proteasome-associated PAD1 homolog 1, 26S proteasome non-ATPase regulatory subunit 14

Immunogen :

KLH-conjugated linear peptide corresponding to 26S proteasome regulatory subunit RPN11.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt