RNA Helicase A/Dhx9 Antibody, clone 8E3 | EMD Millipore MABE878 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RNA Helicase A/Dhx9 Antibody, clone 8E3

catalog :

MABE878

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

8E3

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 1

Reference
O Callaghan P, Noborn F, Sehlin D, Li J, Lannfelt L, Lindahl U, et al. Apolipoprotein E increases cell association of amyloid-? 40 through heparan sulfate and LRP1 dependent pathways. Amyloid. 2014;21:76-87 pubmed publisher

product information

Catalog Number :

MABE878

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-RNA Helicase A/Dhx9 Antibody, clone 8E3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O70133

Host Name :

Rat

Antigen :

Dhx9

Clone :

8E3

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-RNA Helicase A/Dhx9 Antibody, clone 8E3

Cross Reactivity :

Human, Mouse

Background :

RNA Helicase A, also known as DEAH box protein 9 (mHEL-5), DHX9, or Nuclear DNA helicase II (NDH II), and encoded by the mouse gene Dhx9, is a component of the CRD-mediated mRNA stability complex. The CRD-mediated complex is a protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In humans, it consists of IGF2BP1 and at least four additional proteins: HNRNPU, SYNCRIP, YBX1, and RNA Helicase A. RNA Helicase A operates by unwinding dsDNA and RNA in a 3' to 5' direction. Additionally, RNA Helicase A acts as a transcriptional activator and interacts with LARP6 which is a protein that has been associated with fasting glucose traits, type 2 diabetes and obesity as well as the stabilization of collagen mRNAs for CO1A1 and CO1A2. RNA Helicase A is localized to the nucleolus within the nucleus but can also be found in the cytoplasm localized in cytoplasmic mRNP granules containing untranslated mRNAs and thus the protein shuttles between the nucleus and cytoplasm depending upon the microenvironment.

ALT Names :

ATP-dependent RNA helicase A, RHA, DEAH box protein 9, mHEL-5, Nuclear DNA helicase II, NDH II

Immunogen :

KLH-conjugated linear peptide corresponding to the N-terminus of mouse RNA Helicase A/Dhx9.

Package Size :

100 μg

Uses :

Western Blotting, Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt