Mad2 Antibody, clone AS55-A12 | EMD Millipore MABE866 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Mad2 Antibody, clone AS55-A12

catalog :

MABE866

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AS55-A12

reactivity :

human

application :

western blot, immunocytochemistry

citations: 1

Reference
Wild T, Budzowska M, Hellmuth S, Eibes S, Karemore G, Barisic M, et al. Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint. Cell Rep. 2018;25:2317-2328.e5 pubmed publisher

product information

Catalog Number :

MABE866

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Mad2 Antibody, clone AS55-A12

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13257

Host Name :

Mouse

Antigen :

Mad2

Clone :

AS55-A12

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-Mad2 Antibody, clone AS55-A12

Cross Reactivity :

Human

Background :

Mad2, also known as MAD2, MAD2L1, or Mitotic spindle assembly checkpoint protein MAD2A, is a mitotic spindle assembly checkpoint protein. The spindle checkpoint makes sure that all the chromosomes are aligned at the metaphase plate before anaphase begins which means that all chromosomes are attached to the spindle before anaphase can start. The spindle checkpoint becomes triggered when the chromosome(s) are unaligned. Mad2 then binds to the anaphase promoting complex (APC) and CDC20. This complex prevents the cell from transitioning into anaphase and ultimately from cell death or disease.

ALT Names :

Mitotic spindle assembly checkpoint protein MAD2A;HsMAD2;Mitotic arrest deficient 2-like protein 1;MAD2-like protein 1

Immunogen :

His-tagged recombinant protein corresponding to human Mad2.

Package Size :

100 μg

Uses :

Western Blotting;Immunofluorescence

Storage :

Stable for 1 year at 2-8°C from date of receipt