Tristetraprolin Antibody (TTP), clone 1-3 | EMD Millipore MABE65 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tristetraprolin Antibody (TTP), clone 1-3

catalog :

MABE65

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

hTTP-214

reactivity :

human

application :

western blot

product information

Catalog Number :

MABE65

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Tristetraprolin Antibody (TTP), clone 1-3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P26651

Host Name :

Mouse

Antigen :

Tristetraprolin (TTP)

Clone :

hTTP-214

Isotype :

IgG 1

Product Description :

Anti-Tristetraprolin Antibody (TTP), clone 1-3

Cross Reactivity :

Human

Background :

TTP (Tristetraprolin, Nup 475, TIS11, G0S24, or ZFP36) is a member of the CCCH tandem zinc finger protein family. It is a nuclear RNA-binding protein that functions as a trans-acting factor. It is involved in post-transcriptional regulation of cytokine genes, most notably Tumor Necrosis Factor alpha (TNF-α). Upon activation by lipopolysaccharides, TTP binds TNF-α mRNA at AU-rich domains in the 3'-untranslated Region (3'-UTR) and induces deadenylation, thereby destabilizing the mRNA and tagging it for degradation. To produce this effect, TTP recruits other trans-acting factors to its C-terminal domain and mRNA-decay enzymes to its N-terminal domain. TTP is deactivated by phosphorylation driven by mitogen-activated protein kinase-activated protein kinase 2 (MK2) and p53. Therefore, TTP/MK2 regulates the biosynthesis of TNF-α and mediates inflammatory responses involving TNF-α. Knockout of TTP in mice produces arthritis, alopecia, dermatitis, among a range of other phenotypes related to overexpression of TNF-α.

ALT Names :

zinc finger protein 36, C3H type, homolog (mouse);Growth factor-inducible nuclear protein NUP475;Zinc finger protein 36 homolog;G0/G1 switch regulatory protein 24;zinc finger protein, C3H type, 36 homolog (mouse);zinc finger protein, C3H type, 36 homolog;Protein TIS11A

Immunogen :

Recombinant protein corresponding to the human Tristetraprolin (TTP).

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt