macro-H2A1.2 Antibody, clone 14G7 | EMD Millipore MABE61 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

macro-H2A1.2 Antibody, clone 14G7

catalog :

MABE61

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

14G7

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, western blot knockout validation

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; fig 3a	Kim J, Sturgill D, Sebastian R, Khurana S, Tran A, Edwards G, et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. Mol Cell. 2018;69:36-47.e7 pubmed publisher

product information

Catalog Number :

MABE61

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-macro-H2A1.2 Antibody, clone 14G7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O75367

Host Name :

Mouse

Antigen :

macro-H2A1.2

Clone :

14G7

Conjugate :

Purified

Product Description :

Anti-macro-H2A1.2 Antibody, clone 14G7

Cross Reactivity :

Human

Background :

Histone MacroH2A (mH2A), also known as H2AFY, is a vertebrate-specific histone variant associated with condensed, inactive heterochromatin. This histone variant consists of a histone H2A-like domain fused to a large non-histone region. mH2A has been shown to repress RNA polymerase II-driven transcription at the level of transcriptional initiation. The non-histone region of mH2A is directly involved in the repression of transcription, histone acetylation and blocking SWI/SNF and ACF nucleosome remodeling. This variant histone is enriched in chromatin of the female inactive X chromosome and in highly methylated CpG loci.

ALT Names :

H2A histone family, member Y;Histone macroH2A1;Medulloblastoma antigen MU-MB-50.205;histone macroH2A1.1;histone macroH2A1.2;Core histone macro-H2A.1

Immunogen :

GST-tagged recombinant protein corresponding to human macro-H2A1.2.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt