Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody | EMD Millipore MABE578 product information

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody

catalog :

MABE578

quantity :

100 µL

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

EPR5857

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

EMD Millipore product webpage

product information

Catalog Number :

MABE578

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P18754

Host Name :

Rabbit

Antigen :

RCC1

Clone :

EPR5857

Conjugate :

Unpurified

Purification Method :

Unpurified

Isotype :

IgG

Product Description :

Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody

Cross Reactivity :

Human

Background :

The Regulator of Chromosome Condensation 1 (RCC1) is a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. RCC1 is a critical cell cycle regulator, and it interacts with Ran, a nuclear GTP-binding protein. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Studies have shown that RCC1 plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly. RCC1 is involved in regulating the onset of chromosome condensation during S phase. The RCC1 protein binds both to the nucleosomes and double-stranded DNA. The RCC1 complex acts as a guanine-nucleotide dissociation stimulator (GDS) by promoting the loss of bound GDP and the uptake of fresh GTP. Mutations in RCC1 have been assiciated with Raynaud disease.

ALT Names :

Regulator of chromosome condensation, Cell cycle regulatory protein, Chromosome condensation protein 1

Immunogen :

Synthetic peptide corresponding to human RCC1.

Package Size :

100 µL

Uses :

Western Blotting, Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

more info or order :

EMD Millipore product webpage