Anti-phospho-PML (Ser518), clone EPR6151, Rabbit Monoclonal Antibody | EMD Millipore MABE563 product information

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Anti-phospho-PML (Ser518), clone EPR6151, Rabbit Monoclonal Antibody

catalog :

MABE563

quantity :

100 µL

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

EPR6151

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

EMD Millipore product webpage

product information

Catalog Number :

MABE563

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-PML (Ser518), clone EPR6151, Rabbit Monoclonal Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P29590

Host Name :

Rabbit

Antigen :

PML

Clone :

EPR6151

Conjugate :

Unpurified

Purification Method :

Unpurified

Isotype :

IgG

Product Description :

Anti-phospho-PML (Ser518), clone EPR6151, Rabbit Monoclonal Antibody

Cross Reactivity :

Human

Background :

Protein PML, also known as Promyelocytic leukemia protein or RING finger protein 71 or Tripartite motif-containing protein 19, and encoded by the gene name PML or MYL or TRIM19 may function as a transcription factor, a coactivator of nuclear receptors, a regulator of apoptosis, a mediator of interferon-induced antiviral response, and as a suppressor of growth and oncogenic transformation. PML is localized to the nucleoplasm and in distinct subnuclear structures referred to as Promyelocytic Leukemia Bodies (also known as Nuclear Domain 10). Localization of PML to Promyelocytic Leukemia Bodies requires modification of PML protein by the Small Ubiquitin Modifier (SUMO) and is required for proper formation and integrity of these subnuclear structures. At least 14 splice variants of PML ranging in molecular weight from 48-97 kDa (predicted) have been described in the literature. The functional significance of the various splice variants is not well understood. In patients with Acute Promyelocytic Leukemia, the PML gene is involved in at least two specific chromosomal translocations that result in the expression of chimeric proteins with the Retinoic Acid Receptor alpha. All isoforms of PML, as well as the PML-RARalpha chimeric proteins expressed in Type A and Type B APL contain an identical N-terminus but vary in the C-terminal portion of the protein.

ALT Names :

Protein PML, Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19

Immunogen :

Synthetic peptide corresponding to human phospho-PML (Ser518).

Package Size :

100 µL

Uses :

Western Blotting, Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

more info or order :

EMD Millipore product webpage