EMD Millipore

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

antibody

Anti-p57Kip2, clone EP2718(2), Rabbit Monoclonal Antibody

MABE560

100 µL

monoclonal

rabbit

nonconjugated

EP2718

western blot, immunohistochemistry

MABE560

Epigenetics & Nuclear Function

Anti-p57Kip2, clone EP2718(2), Rabbit Monoclonal Antibody

Antibodies

Monoclonal Antibody

P49918

Rabbit

CDKN1C

EP2718(2)

Unpurified

Unpurified

IgG

Anti-p57Kip2, clone EP2718(2), Rabbit Monoclonal Antibody

Human

Cyclin-dependent kinase inhibitor 1C, also known as Cyclin-dependent kinase inhibitor p57 or p57Kip2, and encoded by the gene name CDKN1C or KIP2, is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of the cell in G1 phase. Expression patterns suggest a complex role for p57Kip2 cell cycle control and development. p57Kip2 is located at a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome (BWS). Nonsense mutation found in the Cdk inhibitory domain in a BWS patient rendered p57Kip2 inactive with consequent complete loss of its role as a cell cycle inhibitor and of its nuclear localization. Additionally, the mutation in the QT domain, although completely retaining its cell cycle regulatory activity, lacked nuclear localization and was thus prevented from performing its role as an active cell cycle inhibitor. p57Kip2 is localized in the nucleus and expressed in the heart, brain, lung, skeletal muscle, kidney, eye, pancreas and testis.

Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2

Synthetic peptide corresponding to human p57Kip2.

100 µL

Western Blotting, Immunohistochemistry

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.