monoubiquityl Histone H2B (Lys119) Antibody, clone 7B4 | EMD Millipore MABE453 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

monoubiquityl Histone H2B (Lys119) Antibody, clone 7B4

catalog :

MABE453

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7B4

reactivity :

human

application :

western blot, immunohistochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 4	Zhao M, Song Y, Niu H, Tian Y, Yang X, Xie K, et al. Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy. Oncotarget. 2016;7:8956-67 pubmed publisher

product information

Catalog Number :

MABE453

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-monoubiquityl Histone H2B (Lys119) Antibody, clone 7B4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P62807

Host Name :

Mouse

Antigen :

monoubiquityl Histone H2B (Lys119)

Clone :

7B4

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-monoubiquityl Histone H2B (Lys119) Antibody, clone 7B4

Cross Reactivity :

Human

Background :

H2BUb1, also known as Histone H2B.1 A, or Histone H2B.a (H2B/a), or Histone H2B.g (H2B/g), or Histone H2B.h (H2B/h), or Histone H2B.k (H2B/k) or Histone H2B.i (H2B/I;H2B/I), and encoded by the gene HIST1H2BC or HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI/H2BFL, H2BFH, H2BFG, H2BFA, H2BFK, is a core component of the nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H2BUb1 also has broad antibacterial activity and may contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. H2BUb1 is localized to the nucleus and chromosomes in healthy cells.

ALT Names :

H2BUb1;Histone H2B type 1-C/E/F/G/I;Histone H2B.1 A;Histone H2B.a;H2B/a;Histone H2B.g;H2B/g;Histone H2B.h;H2B/h;Histone H2B.k;H2B/k;Histone H2B.l;H2B/l

Immunogen :

Ovalbumin-conjugated corresponding to human monoubiquityl Histone H2B (Lys119).

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt