phospho Ubiquitin-conjugating enzyme E2 A (Ser120) Antibody, clone 7E4 | EMD Millipore MABE445 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho Ubiquitin-conjugating enzyme E2 A (Ser120) Antibody, clone 7E4

catalog :

MABE445

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

7E4

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

MABE445

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho Ubiquitin-conjugating enzyme E2 A (Ser120) Antibody, clone 7E4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P49459

Host Name :

Mouse

Antigen :

phospho Ubiquitin-conjugating enzyme E2 A (Ser120)

Clone :

7E4

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-phospho Ubiquitin-conjugating enzyme E2 A (Ser120) Antibody, clone 7E4

Cross Reactivity :

Mouse;Human

Background :

Ubiquitin-conjugating enzyme E2 A (UBE2A) is also called RAD6 homolog A (HR6A), Ubiquitin carrier protein A, and Ubiquitin-protein ligase A and is a member of the ubiquitin-conjugating enzyme family. UBE2A accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. UBE2A is involved in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1 (a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and a prerequisite for H3K4me and H3K79me formation), and is required for UV-damaged DNA repair. In vitro, UBE2A catalyzes 'Lys-11' and 'Lys-48'-linked polyubiquitination. Aberrant UBE2A can cause mental retardation syndromic X-linked Nascimento-type (MRXSN).

ALT Names :

Ubiquitin-conjugating enzyme E2 A;RAD6 homolog A;R6A;hHR6A;Ubiquitin carrier protein A;Ubiquitin-protein ligase A

Immunogen :

Linear peptide corresponding to Human phosphorylated Ubiquitin-conjugating enzyme E2 A.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt