Cisplatin DNA Adducts Antibody, clone ICR4 | EMD Millipore MABE416 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cisplatin DNA Adducts Antibody, clone ICR4

catalog :

MABE416

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

1CR4

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:1000; fig 4b	Williamson S, Metcalf R, Trapani F, Mohan S, Antonello J, Abbott B, et al. Vasculogenic mimicry in small cell lung cancer. Nat Commun. 2016;7:13322 pubmed publisher
western blot; mouse; loading ...; fig 4b western blot; rat; loading ...; fig 4a	Zhu J, Carozzi V, Reed N, Mi R, Marmiroli P, Cavaletti G, et al. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep. 2016;6:28861 pubmed publisher
	Zhang M, Du W, Acklin S, Jin S, Xia F. SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. J Clin Invest. 2020;130:2953-2965 pubmed publisher

product information

Catalog Number :

MABE416

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Cisplatin DNA Adducts Antibody, clone ICR4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Host Name :

Rat

Antigen :

Cisplatin DNA Adducts

Clone :

1CR4

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Cisplatin DNA Adducts Antibody, clone ICR4

Cross Reactivity :

Human

Background :

Cisplatin adducts are Guanine-Guanine (GG) DNA intrastrand cross links caused by the chemical compound Cisplatin. Cisplatin is used as a chemotherapy agent that contains platinum. The crosslinking of the DNA triggers apoptosis in the effected cell. Cisplatin is particularly effective in certain cancers such as testicular cancer. Unfortunately like most chemotherapy agents Cisplatin has many side effects and cancer cells typically will develop resistance to the drug after a period of time. Clone ICR4 was formerly known as clone CP9/19.

ALT Names :

CP9/19;Cisplatin, DNA modification

Immunogen :

Cisplatin modified native DNA.

Specificity :

This antibody demonstrates specificity for cisplatin modified DNA.

Package Size :

100 μg

Uses :

Dot Blot;ELISA;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt