acetyl Histone H2A.Z (Lys4/7/11) Antibody, clone 299/39 | EMD Millipore MABE368 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

acetyl Histone H2A.Z (Lys4/7/11) Antibody, clone 299/39

catalog :

MABE368

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

299/39

reactivity :

human

application :

western blot

product information

Catalog Number :

MABE368

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-acetyl Histone H2A.Z (Lys4/7/11) Antibody, clone 299/39

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P0C0S5

Host Name :

Mouse

Antigen :

acetyl Histone H2A.Z (Lys4/7/11)

Clone :

299/39

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-acetyl Histone H2A.Z (Lys4/7/11) Antibody, clone 299/39

Cross Reactivity :

Human

Background :

H2A.Z, also known as H2AFZ, is a variant of histone H2A that is highly conserved from yeast to humans. Like other histone variants, H2A.Z is encoded by a unique gene, resulting in a slightly divergent type of H2A with specialized functions. H2A.Z is involved in chromatin compaction by stabilizing the histone octamer within the nucleosome. It promotes gene expression through the creation of an open domain of chromatin that is more easily transcribed. H2A.Z is nonrandomly distributed throughout the genome, targeted primarily to pericentric heterochromatin, but excluded from the inactive X chromosome and the nucleolus. H2A.Z is associated with both euchromatin and facultative heterochromatin. DNA methylation can influence chromatin structure and effect gene silencing by excluding H2A.Z, and likewise, H2A.Z protects genes from DNA methylation. Thus, H2A.Z plays a role in regulating heterochromatin silencing and is involved in transcriptional control.

ALT Names :

Histone H2A.Z;H2A/z

Immunogen :

Linear peptide corresponding to human acetyl-Histone H2A.Z (Lys4/7/11).

Specificity :

This antibody does not cross react with non-acetyl Histone H2A.Z. Additionally, this antibody does not cross react with acetyl Histone H2A (Lys4/8) or acetyl Histone H4 (Lys 4/7/11) (Prof. J. Trimmer, University of California, Davis.).

Package Size :

100 μg

Uses :

Western Blotting;Dot Blot

Storage :

Stable for 1 year at 2-8°C from date of receipt