EZH2 Antibody, clone AE25 | EMD Millipore MABE362 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

EZH2 Antibody, clone AE25

catalog :

MABE362

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AE25

reactivity :

human

application :

western blot, immunohistochemistry

citations: 1

Reference
Pietersen A, Horlings H, Hauptmann M, Langerød A, Ajouaou A, Cornelissen Steijger P, et al. EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Breast Cancer Res. 2008;10:R109 pubmed publisher

product information

Catalog Number :

MABE362

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-EZH2 Antibody, clone AE25

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q15910

Host Name :

Mouse

Antigen :

EZH2

Clone :

AE25

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-EZH2 Antibody, clone AE25

Cross Reactivity :

Human

Background :

EZH2 (enhancer of zeste homologue 2), also known as Enx1, is a member of the polycomb group of proteins and is involved in cell cycle regulation. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27 trimethylation. EZH2 is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, EZH2 is restricted to the spleen, testis, and placenta. EZH2 and BMI-1 genes are coexpressed in Reed-Sternberg cells of Hodgkin’s disease. Coexpression of BMI-1 and EZH2 is also associated with cycling cells and degree of malignancy in B-cell non-Hogkin’s lymphoma. EZH2 is involved in the progression of prostate cancer, and has been identified as a marker of aggressive breast cancer. Two transcript variants encoding distinct isoforms have been identified for this gene.

ALT Names :

Enhancer of zeste homolog 2;Lysine N-methyltransferase 6;enhancer of zeste 2;histone-lysine N-methyltransferase EZH2

Immunogen :

MBP-tagged recombinant protein corresponding to human EZH2.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt