H2A.Z.2.2 Antibody, clone 1H11-11 | EMD Millipore MABE347 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

H2A.Z.2.2 Antibody, clone 1H11-11

catalog :

MABE347

quantity :

100 µL

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

1H11-11

reactivity :

human

application :

western blot

product information

Catalog Number :

MABE347

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-H2A.Z.2.2 Antibody, clone 1H11-11

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P0C0S5

Host Name :

Rat

Antigen :

H2A.Z.2.2

Clone :

1H11-11

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-H2A.Z.2.2 Antibody, clone 1H11-11

Cross Reactivity :

Human

Background :

H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant. H2A.Z, also known as H2AFZ, is a variant of histone H2A variant that is highly conserved from yeast to humans. H2A.Z is involved in chromatin compaction by stabilizing the histone octamer within the nucleosome. It promotes gene expression through the creation of an open domain of chromatin that is more easily transcribed. H2A.Z is associated with both euchromatin and facultative heterochromatin. DNA methylation can influence chromatin structure and effect gene silencing by excluding H2A.Z, and likewise, H2A.Z protects genes from DNA methylation. Thus, H2A.Z plays a role in regulating heterochromatin silencing and is involved in transcriptional control. H2A.Z.2.2 has been demonstrated to cause nucleosome destabilization.

ALT Names :

Histone H2A.Z;H2A/z

Immunogen :

BSA-conjugated linear peptide corresponding to the C-terminus of human H2A.Z.2.2.

Specificity :

This antibody recognizes the C-terminus of H2A.Z.2.2, but does not demonstrate cross reactivity with H2A.Z.2.1 (Bonisch, C., et al. (2012). Nucleic Acids Research. 1-14).

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt