p53 (wild type) Antibody, clone PAb1620 | EMD Millipore MABE339 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p53 (wild type) Antibody, clone PAb1620

catalog :

MABE339

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Pab1620

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 6a	Li Q, Ye L, Zhang X, Wang M, Lin C, Huang S, et al. FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/Î²-catenin signaling. Cancer Lett. 2017;402:166-176 pubmed publisher
immunoprecipitation; human; fig 6 immunoprecipitation; mouse; fig 4	Huang Y, Bulavin D. Oncogene-mediated regulation of p53 ISGylation and functions. Oncotarget. 2014;5:5808-18 pubmed
	Aggarwal M, Saxena R, Sinclair E, Fu Y, Jacobs A, Dyba M, et al. Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth. Cell Death Differ. 2016;23:1615-27 pubmed publisher
	Liu X, Yang W, Zheng P. Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas. Oncotarget. 2014;5:10870-85 pubmed
	Heyduk E, Heyduk T. Ribosome display enhanced by next generation sequencing: a tool to identify antibody-specific peptide ligands. Anal Biochem. 2014;464:73-82 pubmed publisher
	Saha M, Jiang H, Yang Y, Reece D, Chang H. PRIMA-1Met/APR-246 displays high antitumor activity in multiple myeloma by induction of p73 and Noxa. Mol Cancer Ther. 2013;12:2331-41 pubmed publisher
	Lanni C, Necchi D, Pinto A, Buoso E, Buizza L, Memo M, et al. Zyxin is a novel target for ?-amyloid peptide: characterization of its role in Alzheimer's pathogenesis. J Neurochem. 2013;125:790-9 pubmed publisher
	Puca R, Nardinocchi L, Porru M, Simon A, Rechavi G, Leonetti C, et al. Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs. Cell Cycle. 2011;10:1679-89 pubmed

product information

Catalog Number :

MABE339

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-p53 (wild type) Antibody, clone PAb1620

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P02340

Host Name :

Mouse

Antigen :

p53 (wild type)

Clone :

Pab1620

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-p53 (wild type) Antibody, clone PAb1620

Cross Reactivity :

Human;Mouse

Background :

Wild-type p53 is present in the nucleus of all normal mammalian cells where it appears to be involved in the regulation of cell proliferation. The normal protein has a very short half-life and is present in only minute amounts in normal tissues and cells. In contrast, mutant p53 protein produced by malignant cells is usually a product of a point mutation in the p53 gene leading to substitution of a single amino acid that significantly prolongs the half-life of the protein. The accumulation of high levels of p53 is a potential novel marker for malignancy.

ALT Names :

Cellular tumor antigen p53;Tumor suppressor p53

Immunogen :

Mouse VLM tumor cells.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt