N-Myc Antibody, clone NCM II 100 | EMD Millipore MABE333 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

N-Myc Antibody, clone NCM II 100

catalog :

MABE333

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

NCM II 100

The same clone is also sold as:

Abcam: ab16898
Santa Cruz Biotechnology: sc-56729

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 3a, 3i	Sin Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, et al. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Cancer Cell. 2019;36:51-67.e7 pubmed publisher
immunoprecipitation; human	Sabò A, Doni M, Amati B. SUMOylation of Myc-family proteins. PLoS ONE. 2014;9:e91072 pubmed publisher
western blot; human; 1:100	Ben Yehudah A, Campanaro B, Wakefield L, Kinney T, Brekosky J, Eisinger V, et al. Nicotine exposure during differentiation causes inhibition of N-myc expression. Respir Res. 2013;14:119 pubmed publisher
	Hossain M, Abe Y, Ali F, Youssef M, Honsho M, Fujiki Y, et al. Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-κB Signal Leading to Microglial Activation. J Neurosci. 2017;37:4074-4092 pubmed publisher
	Das S, Foley N, Bryan K, Watters K, Bray I, Murphy D, et al. MicroRNA mediates DNA demethylation events triggered by retinoic acid during neuroblastoma cell differentiation. Cancer Res. 2010;70:7874-81 pubmed publisher
	Chevrier L, Meunier A, Cochaud S, Muller J, Chadéneau C. Vasoactive intestinal peptide decreases MYCN expression and synergizes with retinoic acid in a human MYCN-amplified neuroblastoma cell line. Int J Oncol. 2008;33:1081-9 pubmed
	Blaheta R, Michaelis M, Natsheh I, Hasenberg C, Weich E, Relja B, et al. Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium. Br J Cancer. 2007;96:1699-706 pubmed
	Zindy F, Uziel T, Ayrault O, Calabrese C, Valentine M, Rehg J, et al. Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res. 2007;67:2676-84 pubmed

product information

Catalog Number :

MABE333

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-N-Myc Antibody, clone NCM II 100

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P04198

Host Name :

Mouse

Antigen :

N-Myc

Clone :

NCM II 100

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-N-Myc Antibody, clone NCM II 100

Cross Reactivity :

Human

Background :

The v-myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans the family consists of five genes: c-myc, N-myc, R-myc, L-myc and B-myc. Amplification of the N-myc gene has been found in human neuroblastomas and cell lines. The extent of N-myc amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-myc gene gives rise to at least two nuclear phosphoproteins that exhibit relatively short (30 min) half lives in vivo and exhibit DNA binding properties in vitro.

ALT Names :

N-myc proto-oncogene protein;Class E basic helix-loop-helix protein 37;bHLHe37

Immunogen :

Recombinant protein corresponding to human N-Myc.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt