MDM2 Antibody, clone 4B2C1.11 | EMD Millipore MABE331 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MDM2 Antibody, clone 4B2C1.11

catalog :

MABE331

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B2C1.11

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1a	Bonacci T, Audebert S, Camoin L, Baudelet E, Iovanna J, Soubeyran P. Regulation of NUB1 Activity through Non-Proteolytic Mdm2-Mediated Ubiquitination. PLoS ONE. 2017;12:e0169988 pubmed publisher
	Arena G, Cissé M, Pyrdziak S, Chatre L, Riscal R, Fuentes M, et al. Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53. Mol Cell. 2018;69:594-609.e8 pubmed publisher

product information

Catalog Number :

MABE331

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-MDM2 Antibody, clone 4B2C1.11

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q00987

Host Name :

Mouse

Antigen :

MDM2

Clone :

4B2C1.11

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-MDM2 Antibody, clone 4B2C1.11

Cross Reactivity :

Human;Mouse

Background :

MDM2 is over-expressed in many tumors. Its principal function is the ubiquitination and degradation of p53 tumour suppressor protein. This monoclonal antibody also recognizes a peptide epitope around Thr-216 of murine MDM2 when Thr-216 is unphosphorylated. SMP14 also cross reacts with some cytokeratins (6, 14 & 16). This is only a problem when working with certain epithelial cells and not fibroblasts.

ALT Names :

E3 ubiquitin-protein ligase Mdm2;Double minute 2 protein;Hdm2;Oncoprotein Mdm2;p53-binding protein Mdm2

Immunogen :

Recombinant protein corresponding to human MDM2.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt