| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; 1:1000; loading ...; fig s3a
| Senturk S, Shirole N, Nowak D, Corbo V, Pal D, Vaughan A, et al. Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization. Nat Commun. 2017;8:14370 pubmed publisher |
- immunocytochemistry; human; fig 7
- western blot; human; fig 7
| Hampp S, Kiessling T, Buechle K, Mansilla S, Thomale J, Rall M, et al. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016;113:E4311-9 pubmed publisher |
- western blot; human; fig 4
| Wang Y, Xu Q, Sack L, Kang C, Elledge S. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes Dev. 2016;30:293-306 pubmed publisher |
- chromatin immunoprecipitation; human; fig ed4b
| Zhu J, Sammons M, Donahue G, Dou Z, Vedadi M, Getlik M, et al. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature. 2015;525:206-11 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1 ug/ml
| Adduri R, Kotapalli V, Gupta N, Gowrishankar S, Srinivasulu M, Ali M, et al. P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue. BMC Clin Pathol. 2014;14:37 pubmed publisher |
- immunocytochemistry; human; fig 3
- western blot; human; fig 2
| Senturk S, Yao Z, Camiolo M, Stiles B, Rathod T, Walsh A, et al. p53? is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc Natl Acad Sci U S A. 2014;111:E3287-96 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50
| Agoston A, Odze R. Evidence that gastric pit dysplasia-like atypia is a neoplastic precursor lesion. Hum Pathol. 2014;45:446-55 pubmed publisher |
- western blot; human; 1:500
| Chen Y, Kamili A, Hardy J, Groblewski G, Khanna K, Byrne J. Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle. 2013;12:3083-97 pubmed publisher |
- western blot; human; 1:1000
| Sangar F, Schreurs A, Umana Diaz C, Claperon A, Desbois Mouthon C, Calmel C, et al. Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis. Oncogene. 2014;33:2758-67 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100
| Lauxen I, Oliveira M, Rados P, Lingen M, Nor J, Sant Ana Filho M. Immunoprofiling of oral squamous cell carcinomas reveals high p63 and survivin expression. Oral Dis. 2014;20:e76-80 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Bosco Clément G, Zhang F, Chen Z, Zhou H, Li H, Mikami I, et al. Targeting Gli transcription activation by small molecule suppresses tumor growth. Oncogene. 2014;33:2087-97 pubmed publisher |
- chromatin immunoprecipitation; human
| Kuwahara Y, Wei D, Durand J, Weissman B. SNF5 reexpression in malignant rhabdoid tumors regulates transcription of target genes by recruitment of SWI/SNF complexes and RNAPII to the transcription start site of their promoters. Mol Cancer Res. 2013;11:251-60 pubmed publisher |
| Coffey K, Blackburn T, Cook S, Golding B, Griffin R, Hardcastle I, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS ONE. 2012;7:e45539 pubmed publisher |
- western blot; mouse; 1:2000
- western blot; human; 1:2000; fig 6
| Wade M, Rodewald L, Espinosa J, Wahl G. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle. 2008;7:1973-82 pubmed |
| Wu H, Li S, Hu J, Yu X, Xu H, Chen Z, et al. Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells. J Exp Clin Cancer Res. 2016;35:145 pubmed publisher |
| Bhardwaj V, Noto J, Wei J, Andl C, El Rifai W, Peek R, et al. Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. Oncotarget. 2015;6:1531-43 pubmed |
| Ling X, Xu C, Fan C, Zhong K, Li F, Wang X. FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX. Cancer Res. 2014;74:7487-97 pubmed publisher |
| Zhou X, Tolstov Y, Arslan A, Roth W, Grüllich C, Pahernik S, et al. Harnessing the p53-PUMA axis to overcome DNA damage resistance in renal cell carcinoma. Neoplasia. 2014;16:1028-35 pubmed publisher |
| Ma L, Maruwge W, Strambi A, D Arcy P, Pellegrini P, Kis L, et al. SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth. Cell Death Dis. 2014;5:e1483 pubmed publisher |
| Iannetti A, Ledoux A, Tudhope S, Sellier H, Zhao B, Mowla S, et al. Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet. 2014;10:e1004642 pubmed publisher |
| Wang S, Sun W, Zhao Y, McEachern D, Meaux I, Barrière C, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res. 2014;74:5855-65 pubmed publisher |
| Oi N, Yuan J, Malakhova M, Luo K, Ryu J, Zhang L, et al. Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Oncogene. 2015;34:2660-71 pubmed publisher |
| Dolfi S, Jäger A, Medina D, Haffty B, Yang J, Hirshfield K. Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs. Cancer Lett. 2014;350:52-60 pubmed publisher |
| Morita A, Tanimoto K, Murakami T, Morinaga T, Hosoi Y. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells. Biochem Biophys Res Commun. 2014;443:1286-90 pubmed publisher |
| Farrand L, Kim J, Byun S, Im aram A, Lee J, Suh J, et al. The diarylheptanoid hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of apoptosis-inducing factor and X-linked inhibitor of apoptosis. J Biol Chem. 2014;289:1723-31 pubmed publisher |
| Miki T, Matsumoto T, Zhao Z, Lee C. p53 regulates Period2 expression and the circadian clock. Nat Commun. 2013;4:2444 pubmed publisher |
| Amengual J, Clark Garvey S, Kalac M, Scotto L, Marchi E, Neylon E, et al. Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma. Blood. 2013;122:2104-13 pubmed publisher |
| Leko V, Park G, Lao U, Simon J, Bedalov A. Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. PLoS ONE. 2013;8:e66283 pubmed publisher |
| Brochier C, Dennis G, Rivieccio M, McLaughlin K, Coppola G, Ratan R, et al. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci. 2013;33:8621-32 pubmed publisher |
| Wang H, Cai S, Ernstberger A, Bailey B, Wang M, Cai W, et al. Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways. Clin Cancer Res. 2013;19:2699-709 pubmed publisher |
| MacCallum S, Groves M, James J, Murray K, Appleyard V, Prescott A, et al. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 2013;3:1275 pubmed publisher |
| van den Boom V, Rozenveld Geugien M, Bonardi F, Malanga D, van Gosliga D, Heijink A, et al. Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells. Blood. 2013;121:2452-61 pubmed publisher |
| Basile V, Belluti S, Ferrari E, Gozzoli C, Ganassi S, Quaglino D, et al. bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS ONE. 2013;8:e53664 pubmed publisher |
| Bhattacharya S, Chaum E, Johnson D, Johnson L. Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association. Invest Ophthalmol Vis Sci. 2012;53:8350-66 pubmed publisher |
| Smith S, Enge M, Bao W, Thullberg M, Costa T, Olofsson H, et al. Protein kinase C? (PKC?) regulates p53 localization and melanoma cell survival downstream of integrin ?v in three-dimensional collagen and in vivo. J Biol Chem. 2012;287:29336-47 pubmed publisher |
| Lafontaine J, Tchakarska G, Rodier F, Mes Masson A. Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress. BMC Cancer. 2012;12:234 pubmed publisher |
| Li X, Chen J, Yi Y, Li C, Zhang Y. DNA damage down-regulates ?Np63? and induces apoptosis independent of wild type p53. Biochem Biophys Res Commun. 2012;423:338-43 pubmed publisher |
| Kudo T, Ikeda M, Nishikawa M, Yang Z, Ohno K, Nakagawa K, et al. The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53. Cancer Res. 2012;72:2901-11 pubmed publisher |
| Wurm T, Wright D, Polakowski N, Mesnard J, Lemasson I. The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP. Nucleic Acids Res. 2012;40:5910-25 pubmed publisher |
| Hsu C, Peng K, Jhang H, Lin C, Wu S, Chiang C, et al. The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription. Oncogene. 2012;31:2335-49 pubmed publisher |
| Muscolini M, Montagni E, Palermo V, Di Agostino S, Gu W, Abdelmoula Souissi S, et al. The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein. J Biol Chem. 2011;286:39693-702 pubmed publisher |
| Kim J, Lee K, Seol J, Yu K, Chakravarti D, Seo S. Inhibition of p53 acetylation by INHAT subunit SET/TAF-I? represses p53 activity. Nucleic Acids Res. 2012;40:75-87 pubmed publisher |
| Guo Q, Fast W. Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53. J Biol Chem. 2011;286:17069-78 pubmed publisher |
| Benatti P, Dolfini D, Vigano A, Ravo M, Weisz A, Imbriano C. Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Nucleic Acids Res. 2011;39:5356-68 pubmed publisher |
| Croft D, Crighton D, Samuel M, Lourenco F, Munro J, Wood J, et al. p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Res. 2011;21:666-82 pubmed publisher |
| Phillips A, Teunisse A, Lam S, Lodder K, Darley M, Emaduddin M, et al. HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity. J Biol Chem. 2010;285:29111-27 pubmed publisher |
| Tanno B, Sesti F, Cesi V, Bossi G, Ferrari Amorotti G, Bussolari R, et al. Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin. J Biol Chem. 2010;285:29434-45 pubmed publisher |
| Gillotin S, Yap D, Lu X. Mutation at Ser392 specifically sensitizes mutant p53H175 to mdm2-mediated degradation. Cell Cycle. 2010;9:1390-8 pubmed |
| Nicol S, Fuller Pace F. Analysis of the RNA helicase p68 (Ddx5) as a transcriptional regulator. Methods Mol Biol. 2010;587:265-79 pubmed publisher |
| Beck H, Nähse V, Larsen M, Groth P, Clancy T, Lees M, et al. Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J Cell Biol. 2010;188:629-38 pubmed publisher |
| Gomez Cabello D, Callejas S, Benguria A, Moreno A, Alonso J, Palmero I. Regulation of the microRNA processor DGCR8 by the tumor suppressor ING1. Cancer Res. 2010;70:1866-74 pubmed publisher |
| High L, Szymanska B, Wilczynska Kalak U, Barber N, O Brien R, Khaw S, et al. The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs. Mol Pharmacol. 2010;77:483-94 pubmed publisher |
| Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A. LMO3 interacts with p53 and inhibits its transcriptional activity. Biochem Biophys Res Commun. 2010;392:252-7 pubmed publisher |
| Kawamura T, Suzuki J, Wang Y, Menendez S, Morera L, Raya A, et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009;460:1140-4 pubmed publisher |
| Salem M, Shalbaf M, Gibbons N, Chavan B, Thornton J, Schallreuter K. Enhanced DNA binding capacity on up-regulated epidermal wild-type p53 in vitiligo by H2O2-mediated oxidation: a possible repair mechanism for DNA damage. FASEB J. 2009;23:3790-807 pubmed publisher |
| Chatoo W, Abdouh M, David J, Champagne M, Ferreira J, Rodier F, et al. The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci. 2009;29:529-42 pubmed publisher |
| Blickwedehl J, Agarwal M, Seong C, Pandita R, Melendy T, Sung P, et al. Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability. Proc Natl Acad Sci U S A. 2008;105:16165-70 pubmed publisher |
| Gatz S, Keimling M, Baumann C, Dork T, Debatin K, Fulda S, et al. Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner. Carcinogenesis. 2008;29:519-27 pubmed publisher |
| Rizos H, Scurr L, Irvine M, Alling N, Kefford R. p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism. Cell Cycle. 2007;6:1741-7 pubmed |
| Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol. 2007;178:93-105 pubmed |
| Nakanishi M, Ozaki T, Yamamoto H, Hanamoto T, Kikuchi H, Furuya K, et al. NFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage. J Biol Chem. 2007;282:22993-3004 pubmed |
| Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A. The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochem Biophys Res Commun. 2006;351:57-63 pubmed |
| Rizos H, Woodruff S, Kefford R. p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners. Cell Cycle. 2005;4:597-603 pubmed |
