ICBP90/UHRF1 Antibody, clone 1RC1C-10 | EMD Millipore MABE308 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ICBP90/UHRF1 Antibody, clone 1RC1C-10

catalog :

MABE308

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1RC-1C10

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human	Chiang Y, Wang K, Fazli L, Qi R, Gleave M, Collins C, et al. GATA2 as a potential metastasis-driving gene in prostate cancer. Oncotarget. 2014;5:451-61 pubmed
	Kong X, Chen J, Xie W, Brown S, Cai Y, Wu K, et al. Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties. Cancer Cell. 2019;35:633-648.e7 pubmed publisher

product information

Catalog Number :

MABE308

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-ICBP90/UHRF1 Antibody, clone 1RC1C-10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q96T88

Host Name :

Mouse

Antigen :

ICBP90/UHRF1

Clone :

1RC-1C10

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-ICBP90/UHRF1 Antibody, clone 1RC1C-10

Cross Reactivity :

Human

Background :

Ubiquitin-like with PHD and ring finger domains 1 (UHRF1), also known as ICBP90 or Np95, is a multifunctional nuclear protein that may be an important mediator of heterochromatin formation which is indicative of gene repression. UHRF1 contains a set and RING-finger-associated domain that detects hemi-methylated cytosine residues leading to the recruitment of DNMT1 to these residues during the S phase. UHRF1 thereby facilitates the transfer of methylation status to newly synthesized DNA molecules. UHRF1 may also interact with histones and HDAC1 via its PHD domain to promote modifications of histone residues which contribute to heterochromatin formation. UHRF1 may also directly modify histone H3 by ubiquitination. In addition, UHRF1 may contribute to the DNA-repair process though associations with PCNA. Several studies have suggested that overexpression of UHRF1 may contribute to the development of many cancers.

ALT Names :

E3 ubiquitin-protein ligase;inverted CCAAT box-binding protein;Nuclear protein 95;Nuclear zinc finger protein Np95;HuNp95;RING finger protein 106;Transcription factor ICBP90;Ubiquitin-like PHD and RING finger domain-containing protein 1;Ubiquitin-like-containing PHD;and RING finger domains protein 1

Immunogen :

Recombinant protein corresponding to human ICBP90.

Package Size :

100 µL

Uses :

Western Blotting;Chromatin Immunoprecipitation (ChIP);Immunocytochemistry;Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.