Dnmt1 Antibody, clone DNM-2C1 | EMD Millipore MABE306 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Dnmt1 Antibody, clone DNM-2C1

catalog :

MABE306

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

DNM-2C1

reactivity :

human

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

product information

Catalog Number :

MABE306

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Dnmt1 Antibody, clone DNM-2C1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P26358

Host Name :

Rat

Antigen :

Dnmt1

Clone :

DNM-2C1

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-Dnmt1 Antibody, clone DNM-2C1

Cross Reactivity :

Human

Background :

DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is one of three mammalian enzymes that catalyze the addition of a methyl group to the 5’ carbon of cytosine residues in CpG dinucleotides. These methylation marks are heritable modifications that are transferred to new DNA molecules following replication, by the activity of Dnmt1, and possibly Dnmt3a and Dnmt3b. Dnmt1 recognizes hemimethylated CpG regions with the aid of the UHRF1 protein, and it mediates the methylation of cytosines at those sites. DNA methylation has been linked to chromosome stability and gene expression in somatic cells; and to parental imprinting and X-chromosome inactivation in germ cells. Several studies have indicated that DNA methylation patterns are altered in various cancers.

ALT Names :

DNA (cytosine-5)-methyltransferase 1;Dnmt1;CXXC-type zinc finger protein 9;DNA methyltransferase HsaI;DNA Mtase Hsal, M. H.sal, MCMT

Immunogen :

His-tagged recombinant protein corresponding to human Dnmt1.

Package Size :

100 μg

Uses :

Immunoprecipitation;Western Blotting;Chromatin Immunoprecipitation (ChIP)

Storage :

Stable for 1 year at 2-8°C from date of receipt