2,2,7-Trimethylguanosine Antibody, clone K121 | EMD Millipore MABE302 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

2,2,7-Trimethylguanosine Antibody, clone K121

catalog :

MABE302

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

K121

reactivity :

human, mouse

application :

immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section, RNA immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:50; fig 4a	Kobayashi M, Chandrasekhar A, Cheng C, Martinez J, Ng H, de La Hoz C, et al. Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22. Dis Model Mech. 2017;10:215-224 pubmed publisher
immunocytochemistry; human; fig s4c	Ammon T, Mishra S, Kowalska K, Popowicz G, Holak T, Jentsch S. The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells. J Mol Cell Biol. 2014;6:312-23 pubmed publisher
	Jimeno GonzÃ¡lez S, Ceballos ChÃ¡vez M, Reyes J. A positioned +1 nucleosome enhances promoter-proximal pausing. Nucleic Acids Res. 2015;43:3068-78 pubmed publisher
	Hales C, Dammer E, Diner I, Yi H, Seyfried N, Gearing M, et al. Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease. Brain Pathol. 2014;24:344-51 pubmed publisher

product information

Catalog Number :

MABE302

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-2,2,7-Trimethylguanosine Antibody, clone K121

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Host Name :

Mouse

Antigen :

2,2,7-Trimethylguanosine

Clone :

K121

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-2,2,7-Trimethylguanosine Antibody, clone K121

Cross Reactivity :

Human;Mouse

Background :

The 2,2,7-trimethylguanosine cap structure is found on the 5’ end of small nuclear RNAs and small nucleolar RNAs. Initially, these RNA molecules are capped with 7-monomethylguanosine (m7G) which is then methylated by the trimethylguanosine synthase enzyme to form 2,2,7-trimethylguanosine. The synthesis of 2,2,7-trimethylguanosine occurs in the cytoplasm and is an important marker for nuclear localization of RNA molecules. Capping of RNAs is an important requirement for RNA transport and splicing processes. Uncapped RNAs are rapidly degraded by the 5′ exoribonuclease enzyme. 2,2,7-trimethylguanosine capping may play a role in the expression of viral RNAs.

Immunogen :

2,2,7-trimethylguanosine

Package Size :

100 μg

Uses :

Immunocytochemistry;Immunoaffinity Purification;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt