Estrogen Receptor β Antibody, clone 9.88 | EMD Millipore MABE290 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Estrogen Receptor β Antibody, clone 9.88

catalog :

MABE290

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9.88

The same clone is also sold as:

MilliporeSigma: E1276

reactivity :

human, mouse

application :

western blot, immunoprecipitation

product information

Catalog Number :

MABE290

Subcategory :

Cell Signaling

Product Name :

Anti-Estrogen Receptor β Antibody, clone 9.88

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q92731

Host Name :

Mouse

Antigen :

Estrogen Receptor β

Clone :

9.88

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-Estrogen Receptor β Antibody, clone 9.88

Cross Reactivity :

Rat;Mouse;Human

Background :

Estrogen receptor beta (ERβ; NR3A2 or ESR2) is a nuclear steroid receptor that has been detected in the ovary, testis, thymus, spleen, bone, brain, and kidney. It is a multidomain protein containing A/B, C, D, E, and F domains, and it is activated by estrogen, resulting in homo- or heterodimerization (with ERα). The active ERβ-estrogen complex binds to regulatory regions known as estrogen response elements on target genes; however, ERβ may also regulate transcription without a bound ligand via its activation function (AF-1) region in the A/B domain. The ERβ receptor interacts with a wide variety of proteins including transcriptional corepressors and coactivators that regulate its activity. Its expression is also regulated by hypermethylation of CpG islands in the ERβ promoter. Previous studies have reported that ERβ has anti-inflammatory and anti-proliferative effects, and may therefore be an important therapeutic target for cancers, especially those occurring in the reproductive organs.

ALT Names :

Estrogen receptor beta;ER-beta;Nuclear receptor subfamily 3 group A member 2

Immunogen :

Recombinant protein corresponding to human Estrogen Receptor β.

Package Size :

100 µL

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt