MSH2 Antibody, clone FE11 | EMD Millipore MABE284 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MSH2 Antibody, clone FE11

catalog :

MABE284

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

FE11

The same clone is also sold as:

Invitrogen: 33-7900
Abnova: MAB14123
Dako: M3639

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:100; loading ...	Taieb J, Zaanan A, Le Malicot K, Julie C, Blons H, Mineur L, et al. Prognostic Effect of BRAF and KRAS Mutations in Patients With Stage III Colon Cancer Treated With Leucovorin, Fluorouracil, and Oxaliplatin With or Without Cetuximab: A Post Hoc Analysis of the PETACC-8 Trial. JAMA Oncol. 2016;2:643-653 pubmed publisher
immunohistochemistry; human; 1:100	Vanoli A, Argenti F, Vinci A, La Rosa S, Viglio A, Riboni R, et al. Hepatoid carcinoma of the pancreas with lymphoid stroma: first description of the clinical, morphological, immunohistochemical, and molecular characteristics of an unusual pancreatic carcinoma. Virchows Arch. 2015;467:237-45 pubmed publisher
immunohistochemistry; human	Malesci A, Basso G, Bianchi P, Fini L, Grizzi F, Celesti G, et al. Molecular heterogeneity and prognostic implications of synchronous advanced colorectal neoplasia. Br J Cancer. 2014;110:1228-35 pubmed publisher
immunohistochemistry - paraffin section; human; 1:30	Egoavil C, Alenda C, Castillejo A, Paya A, Peiro G, Sanchez Heras A, et al. Prevalence of Lynch syndrome among patients with newly diagnosed endometrial cancers. PLoS ONE. 2013;8:e79737 pubmed publisher
	Vilar E, Mork M, Cuddy A, Borràs E, Bannon S, Taggart M, et al. Role of microsatellite instability-low as a diagnostic biomarker of Lynch syndrome in colorectal cancer. Cancer Genet. 2014;207:495-502 pubmed publisher
	Canard G, Lefevre J, Colas C, Coulet F, Svrcek M, Lascols O, et al. Screening for Lynch syndrome in colorectal cancer: are we doing enough?. Ann Surg Oncol. 2012;19:809-16 pubmed publisher
	Edwards R, Witherspoon M, Wang K, Afrasiabi K, Pham T, Birnbaumer L, et al. Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Res. 2009;69:6423-9 pubmed publisher
	Belvederesi L, Bianchi F, Galizia E, Loretelli C, Bracci R, Catalani R, et al. MSH2 missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system. Hum Mutat. 2008;29:E296-309 pubmed publisher
	Ewald J, Rodrigue C, Mourra N, Lefevre J, Flejou J, Tiret E, et al. Immunohistochemical staining for mismatch repair proteins, and its relevance in the diagnosis of hereditary non-polyposis colorectal cancer. Br J Surg. 2007;94:1020-7 pubmed

product information

Catalog Number :

MABE284

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-MSH2 Antibody, clone FE11

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P43246

Host Name :

Mouse

Antigen :

MSH2

Clone :

FE11

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-MSH2 Antibody, clone FE11

Cross Reactivity :

Human

Background :

MSH2 is a ubiquitously expressed nuclear protein that is involved in DNA repair processes. MSH2 is active as a heterodimer of MutS alpha and beta subunits that bind DNA at mismatched strands. The MutS alpha subunit binds to single base mismatches and dinucleotide insertion-deletion loops, whereas MutS beta detects longer insertion-deletion loops. Bound MutS subunits then form complexes with MutL alpha dimers, to coordinate downstream DNA-mismatch–repair processes. Abnormal expression of MSH2 has been linked to hereditary non-polyposis colorectal cancer type 1 and Muir-Torre syndrome.

ALT Names :

DNA mismatch repair protein Msh2;hMSH2;MutS protein homolog 2

Immunogen :

Recombinant protein corresponding to the C-terminus of human MSH2.

Specificity :

This antibody recognizes the C-terminus of MSH2.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt