GATA3 Antibody, clone 3F1.1 | EMD Millipore MABE271 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GATA3 Antibody, clone 3F1.1

catalog :

MABE271

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3F1.1

reactivity :

human

application :

western blot, flow cytometry

citations: 1

Reference
Merino D, Giam M, Hughes P, Siggs O, Heger K, O Reilly L, et al. The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol. 2009;186:355-62 pubmed publisher

product information

Catalog Number :

MABE271

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-GATA3 Antibody, clone 3F1.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P23771

Host Name :

Mouse

Antigen :

GATA3

Clone :

3F1.1

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-GATA3 Antibody, clone 3F1.1

Cross Reactivity :

Human

Background :

GATA3 is a transcription factor containing a zinc finger domain. GATA3 is primarily expressed in T cells, where it thought to participate in T-cell receptor gene activation through binding to enhancers. Analysis of conditional GATA3 knockout mice confirmed the critical role of GATA3 in helper T cell differentiation and proliferation. Cells expressing GATA3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. Binding of GATA3 in the regulatory regions of the genes of these cytokines alters chromatin structure, increasing accessibility to other transcription factors. T cell receptor activation activates NFAT and other transcription factors that cooperate with GATA3 in inducing Th2 cell differentiation. Blocking GATA3 action has been suggested as a therapeutic strategy to treat asthma. GATA3 has also been implicated in developmental processes such as the development of the inner ear.

ALT Names :

Trans-acting T-cell-specific transcription factor GATA-3;GATA-binding factor 3

Immunogen :

Recombinant protein corresponding to human GATA3.

Package Size :

100 μg

Uses :

Western Blotting;Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt