unmethylated-Histone H3 (Lys9) Antibody, clone 9B1-2G6, Trial Size | EMD Millipore MABE263-S product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

unmethylated-Histone H3 (Lys9) Antibody, clone 9B1-2G6, Trial Size

catalog :

MABE263-S

quantity :

10 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9B1-2G6

The same clone is also sold as:

BioLegend: 815701

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

MABE263-S

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-unmethylated-Histone H3 (Lys9) Antibody, clone 9B1-2G6, Trial Size

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P68433

Host Name :

Mouse

Antigen :

unmethylated-Histone H3 (Lys9)

Clone :

9B1-2G6

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-unmethylated-Histone H3 (Lys9) Antibody, clone 9B1-2G6, Trial Size

Cross Reactivity :

Human

Background :

Histones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli, including phosphorylation on serine and threonine residues and methylation on lysine residues. PTMs produce configural changes in histone proteins that may induce nucleosome remodeling and expose or hide DNA sequences from transcriptional complexes. Methylation occurs on histone H3 at lysine 4, 9, 27, 36, and 79 residues. Previous studies have reported that methylation of H3 lysine 9 provides a binding site for heterochromatin adaptor proteins (HP1) which are involved in the formation of heterochromatin and gene repression. Conversely,deacetylation of histone H3 lysine 9 is associated with gene-activating events. Often, it is the pattern of different modifications on several histone residues that alter chromatin, rather than modification of single residues.

ALT Names :

Histone H3.1

Immunogen :

KLH-conjugated linear peptide corresponding to human unmethylated Histone H3 (Lys9).

Specificity :

This antibody recognizes Histone H3 unmethylated at Lys9. This antibody does not cross react with methyl-Histone (Lys29). This antibody detects unmethylated Histone H3 (Lys9) when Ser10 is phosphorylated. It also detects mono-/di-methyl-Histone H3 (Lys4), and Acetyl-Histone H3 (Lys14). (Prof. E. Ogris, Department of Medical Biochemistry, Medical University of Vienna).

Package Size :

10 µg

Uses :

Western Blotting;Dot Blot

Storage :

Stable for 1 year at 2-8°C from date of receipt