Protein-arginine deiminase 4 Antibody, clone 10F1 | EMD Millipore MABE254 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Protein-arginine deiminase 4 Antibody, clone 10F1

catalog :

MABE254

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10f1

reactivity :

human

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 1

Reference
Sage J, Gildemeister O, Knight K. Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. J Biol Chem. 2010;285:18984-90 pubmed publisher

product information

Catalog Number :

MABE254

Subcategory :

Cell Signaling

Product Name :

Anti-Protein-arginine deiminase 4 Antibody, clone 10F1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9UM07

Host Name :

Mouse

Antigen :

Protein-arginine deiminase 4

Clone :

10F1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Protein-arginine deiminase 4 Antibody, clone 10F1

Cross Reactivity :

Human

Background :

Protein-arginine deiminase type-4 (PAD4; formerly PAD5) is one of five PAD (1-4, 6) homologues that belong to the superfamily of multidomain amidinotransferases. The PAD enzymes catalyze deiminating reactions in which guanidinium is hydrolyzed to peptidylcitrulline. PAD4 is a calcium-regulated nuclear-localized enzyme. It modifies arginine residues on histones H2A, H3, and H4 (H2 Arg3; H3 Arg2, H3 Arg8, H3 Arg17, H3 Arg26; and H4 Arg3). Several studies have suggested that PAD4-mediated citrullination has important implications for gene regulation. PAD4 may perform deimination at sites overlapping with arginine methylation, and antagonize the transcription-promoting effects of methylating enzymes such as CARM1 and PRMT1. PAD4 may therefore inhibit gene expression, most notably expression of cell-cycle regulating p53 genes such as p21. Previous studies have suggested that PAD4 may play central role in the development of cancer.

ALT Names :

HL-60 PAD;Protein-arginine deiminase type-4;Peptidylarginine deiminase IV;Protein-arginine deiminase type IV

Immunogen :

GST-tagged recombinant protein corresponding to human Protein-arginine deminiase 4.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation;Chromatin Immunoprecipitation (ChIP)

Storage :

Stable for 1 year at 2-8°C from date of receipt