Ago2 Antibody, clone 11A9 | EMD Millipore MABE253 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Ago2 Antibody, clone 11A9

catalog :

MABE253

quantity :

200 µL

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

11A9

The same clone is also sold as:

MilliporeSigma: SAB4200085

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, western blot knockout validation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; loading ...; fig 3b immunoprecipitation; human	Eckenfelder A, Segeral E, Pinzón N, Ulveling D, Amadori C, Charpentier M, et al. Argonaute proteins regulate HIV-1 multiply spliced RNA and viral production in a Dicer independent manner. Nucleic Acids Res. 2017;45:4158-4173 pubmed publisher
	Youn J, Dunham W, Hong S, Knight J, Bashkurov M, Chen G, et al. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Mol Cell. 2018;69:517-532.e11 pubmed publisher

product information

Catalog Number :

MABE253

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Ago2 Antibody, clone 11A9

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9UKV8

Host Name :

Rat

Antigen :

Ago2

Clone :

11A9

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Ago2 Antibody, clone 11A9

Cross Reactivity :

Human

Background :

Ago2 (argonaute-2), also known as eukaryotic translation initiation factor 2C (EIF2C2), is an essential component for siRNA-directed RNA interference (RNAi) response. Ago2 is an endonuclease required for the unwinding of siRNA duplex and assembly of siRNA into RNA-induced silencing complexes (RISC). Ago2 interacts with DICER1 through its Piwi domain. This Piwi domain is thought to provide RNA cleavage activity via a mechanism similar to RNase H. Ago2 activity is necessary for embryonic development as well as RNA-mediated gene silencing (RNAi).

ALT Names :

Protein argonaute-2;Argonaute2;hAgo2;Eukaryotic translation initiation factor 2C 2;eIF-2C 2;eIF2C 2;PAZ Piwi domain protein;PPD;Protein slicer

Immunogen :

Linear peptide corresponding to human Ago2.

Package Size :

200 µL

Uses :

Western Blotting;Immunoprecipitation;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt