5-hydroxymethylcytosine (5hmC) Antibody, clone HMC 31 | EMD Millipore MABE251 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

5-hydroxymethylcytosine (5hmC) Antibody, clone HMC 31

catalog :

MABE251

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HMC 31

citations: 1

Reference
Glowacka W, Jain H, Okura M, Maimaitiming A, Mamatjan Y, Nejad R, et al. 5-Hydroxymethylcytosine preferentially targets genes upregulated in isocitrate dehydrogenase 1 mutant high-grade glioma. Acta Neuropathol. 2018;135:617-634 pubmed publisher

product information

Catalog Number :

MABE251

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone HMC 31

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Host Name :

Mouse

Antigen :

5-hydroxymethylcytosine (5hmC)

Clone :

HMC 31

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone HMC 31

Cross Reactivity :

All

Background :

5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base formed from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of iron-dependent oxygenases. Data suggests that every mammilian cell contains 5-hydroxymethylcytosine, but the levels vary depending on the cell type; data also suggests that levels of 5-hydroxymethylcytosine increases with age. The highest levels are found in neuronal cells of the central nervous system and certain mammalian tissues such as mouse Purkinje and granule neurons. Although the exact function has not been fully elucidated, studies suggest that 5-hydroxymethlcytosine may regulate gene expression or initiate DNA demethylation.

Immunogen :

BSA-conjugated 5-hydroxymethylcytosine.

Specificity :

This antibody recognizes the 5-hydroxymethylcytosine of 5-Hydroxymethylcytosine DNA.

Package Size :

100 μg

Uses :

Dot Blot;Methylated DNA Immunoprecipitation (MeDIP);ELISA

Storage :

Stable for 1 year at 2-8°C from date of receipt