SMN2 Antibody, clone SMN-KH | EMD Millipore MABE230 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SMN2 Antibody, clone SMN-KH

catalog :

MABE230

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SMN-KH

reactivity :

human

application :

western blot, immunohistochemistry

citations: 1

Reference
Seo J, Singh N, Ottesen E, Sivanesan S, Shishimorova M, Singh R. Oxidative Stress Triggers Body-Wide Skipping of Multiple Exons of the Spinal Muscular Atrophy Gene. PLoS ONE. 2016;11:e0154390 pubmed publisher

product information

Catalog Number :

MABE230

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-SMN2 Antibody, clone SMN-KH

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q16637

Host Name :

Mouse

Antigen :

SMN2

Clone :

SMN-KH

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-SMN2 Antibody, clone SMN-KH

Cross Reactivity :

Human

Background :

Survival of Motor Neuron (SMN) is expressed from two linked paralogous genes, SMN1 and SMN2. SMNs are primarily localized in the cytoplasm and nuclear gems of all cells, where they are understood to mediate the assembly of spliceosomal small nuclear ribonucleoprotein particles (snRNPs). They also play a role in the metabolism of snoRNPs and are required for the splicing of pre-mRNA in the nucleus. The progressive loss of functional SMNs in the anterior horn of the spinal cord is a critical cause of Spinal Muscular Atrophy (SMA), an autosomal recessive neuromuscular disease. There are three known types of childhood-onset SMA, in addition to a fourth type that is characterized by adult-onset SMA.

ALT Names :

Survival motor neuron protein;Component of gems 1;Gemin-1

Immunogen :

MBP-tagged recombinant protein corresponding to human SMN2.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt