FTO Antibody, clone 5-2H10 | EMD Millipore MABE227 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

FTO Antibody, clone 5-2H10

catalog :

MABE227

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5-2H10

The same clone is also sold as:

Invitrogen: MA5-33105
Abnova: MAB12718
Rockland Immunochemicals: 200-301-D41
LifeSpan Biosciences: LS-B7982
OriGene: TA309122
Abcam: ab92821

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1	Singh B, Kinne H, Milligan R, Washburn L, Olsen M, Lucci A. Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge. PLoS ONE. 2016;11:e0159072 pubmed publisher
	Engel M, Eggert C, Kaplick P, Eder M, Röh S, Tietze L, et al. The Role of m6A/m-RNA Methylation in Stress Response Regulation. Neuron. 2018;99:389-403.e9 pubmed publisher

product information

Catalog Number :

MABE227

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-FTO Antibody, clone 5-2H10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9C0B1

Host Name :

Mouse

Antigen :

FTO

Clone :

5-2H10

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-FTO Antibody, clone 5-2H10

Cross Reactivity :

Human;Rat

Background :

Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) is a ubiquitous nuclear protein which belongs to the FTO family. It is a dioxygenase enzyme that dealkylates nucleic acids by oxidative demethylation in the presence of oxygen, alpha-ketoglutarate and iron (Fe2+). FTO is highly active on single-stranded RNA molecules with 3-methyluracil residues and on single-stranded DNA containing 3-methylthymine residues, and has relatively low activity on single-stranded DNA containing either 3-methylcytosine or 3-methyladenine. There has been no observed activity on double-stranded DNA. FTO is highly abundant in the hypothalamus, pituitary, and adrenal glands. It plays an important role in energy homeostasis and the regulation of fat accumulation in the body, and may be involved in obesity. Mutated FTO proteins are linked to a syndrome characterized by retarded growth, delayed development, coarse facies and early death.

ALT Names :

Alpha-ketoglutarate-dependent dioxygenase FTO;Fat mass and obesity-associated protein

Immunogen :

Recombinant protein corresponding to human FTO.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt