WHSC1/NSD2 Antibody, clone 29D1 | EMD Millipore MABE191 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

WHSC1/NSD2 Antibody, clone 29D1

catalog :

MABE191

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

29D1

The same clone is also sold as:

Abcam: ab75359
Active Motif: 39879

reactivity :

human, mouse

application :

western blot, immunoprecipitation, chromatin immunoprecipitation, western blot knockout validation

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; loading ...; fig e4a	Weinberg D, Papillon Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan K, et al. The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape. Nature. 2019;573:281-286 pubmed publisher
western blot; human; loading ...; fig 4a	Papillon Cavanagh S, Lu C, Gayden T, Mikael L, Bechet D, Karamboulas C, et al. Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas. Nat Genet. 2017;49:180-185 pubmed publisher
western blot; mouse; fig s10c	Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352:844-9 pubmed publisher
	Yuan S, Natesan R, Sanchez Rivera F, Li J, Bhanu N, Yamazoe T, et al. Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression. Cancer Discov. 2020;10:854-871 pubmed publisher

product information

Catalog Number :

MABE191

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-WHSC1/NSD2 Antibody, clone 29D1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O96028

Host Name :

Mouse

Antigen :

WHSC1/NSD2

Clone :

29D1

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-WHSC1/NSD2 Antibody, clone 29D1

Cross Reactivity :

Human

Background :

Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), Nuclear SET domain containing protein 2 (NSD2) is a histone lysine methyltransferase that is deregulated in a subgroup of multiple myelomas. NSD proteins have been described to serve as oncogenes; however, little is known about their targets in transcriptional repression or activation. NSD2 is overexpressed in multiple myelomas via translocation between the NSD2 locus on chromosome 4 and the immunoglobulin locus on chromosome 14. NSD2 is under the regulatory control of this immunoglobulin locus. Further research is required to elucidate its roles and mechanisms in cancer.

ALT Names :

Probable histone-lysine N-methyltransferase NSD2;Multiple myeloma SET domain-containing protein;Nuclear SET domain-containing protein 2;Protein trithorax-5;Wolf-Hirschhorn syndrome candidate 1 protein

Immunogen :

GST-tagged recombinant protein corresponding to human WHSC1/NSD2.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation;Chromatin Immunoprecipitation (ChIP)

Storage :

Stable for 1 year at 2-8°C from date of receipt