PARP-2 Antibody, clone 4G8 | EMD Millipore MABE18 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PARP-2 Antibody, clone 4G8

catalog :

MABE18

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G8

The same clone is also sold as:

Enzo Life Sciences: ALX-804-639-L001

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, western blot knockout validation

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; 1:1000; loading ...; fig 1e	Chen Q, Kassab M, Dantzer F, Yu X. PARP2 mediates branched poly ADP-ribosylation in response to DNA damage. Nat Commun. 2018;9:3233 pubmed publisher
immunohistochemistry; human	Tapia Rojas C, Aranguiz F, Varela Nallar L, Inestrosa N. Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease. Brain Pathol. 2016;26:62-74 pubmed publisher
western blot; human; fig 2h	Bachmann S, Frommel S, Camicia R, Winkler H, Santoro R, Hassa P. DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. Mol Cancer. 2014;13:125 pubmed publisher

product information

Catalog Number :

MABE18

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-PARP-2 Antibody, clone 4G8

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O88554

Host Name :

Mouse

Antigen :

PARP-2

Clone :

4G8

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-PARP-2 Antibody, clone 4G8

Cross Reactivity :

Human;Mouse

Background :

Poly(ADP-ribose) polymerase (PARP) is a highly conserved nuclear enzyme present in higher eukaryotes. This gene is a member of a family of enzymes that synthesize and transfer ADP-ribose polymers to protein to modify their functional properties. A key role of PARP in the cell is mediating the repair of single-strand DNA nicks. PARP-2 forms homodimers and hetero dimers with PARP-1 in the base excision repair (BER) pathway. To mediate repair PARP interacts with DNA and recruits DNA repair protein XRCC1, DNA ligase III, DNA polymerase beta and a kinase to the site of damage. As a marker for apoptosis, it has been shown that PARP cleavage mediated by caspase-3 activity occurs at the onset of apoptosis, and inhibition of PARP cleavage attenuates apoptosis in vitro.

ALT Names :

Poly [ADP-ribose] polymerase 1;PARP-1;NAD(+) ADP-ribosyltransferase 1;ADPRT 1;Poly[ADP-ribose] synthase 1;ARTD1

Immunogen :

Recombinant protein corresponding to mouse PARP-2.

Specificity :

This antibody recognizes PARP-2.

Package Size :

100 μg

Uses :

Western Blotting;ELISA;Immunoprecipitation;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt