Ago1 Antibody, clone 4G7-E12 | EMD Millipore MABE143 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Ago1 Antibody, clone 4G7-E12

catalog :

MABE143

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G7-E12

reactivity :

human

application :

western blot

citations: 1

Reference
Tarallo R, Giurato G, Bruno G, Ravo M, Rizzo F, Salvati A, et al. The nuclear receptor ER? engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Genome Biol. 2017;18:189 pubmed publisher

product information

Catalog Number :

MABE143

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Ago1 Antibody, clone 4G7-E12

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9UL18

Host Name :

Mouse

Antigen :

Ago1

Clone :

4G7-E12

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Ago1 Antibody, clone 4G7-E12

Cross Reactivity :

Human

Background :

Ago1 (Eukaryotic translation initiation factor 2C 1) belongs to the argonaute family and contains 1 PAZ and 1 Piwi domain. It is required for G1 arrest and mating in response to nitrogen starvation. It is also known as a cell cycle control protein through its regulation of cytokinesis and its related cell cycle checkpoints, which occur downstream of dcr1. It is required, indirectly, for regulated hyperphosphorylation of cdc2. Ago 1 also has a role in the RNA interference (RNAi) pathway, which is important for heterochromatin formation and accurate chromosome segregation. It has been shown to be non-essential for siRNA-directed target RNA cleavage, but is needed for the production of mature miRNA that affects miRNA-directed RNA cleavage.

ALT Names :

hAgo1;Argonaute1;eIF-2C 1;eIF2C 1;Q99;GERP95;DKFZp686M13167

Immunogen :

GST-tagged recombinant protein corresponding to human Ago1.

Specificity :

This antibody has been shown by an independent laboratory to not cross react with Ago2, Ago3, or Ago4 (Azuma-Mukai A et al. (2008) Proc. Natl. Acad. Sci. USA 105: 7964-7969).

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt