SR protein family Antibody, clone 16H3 | EMD Millipore MABE126 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SR protein family Antibody, clone 16H3

catalog :

MABE126

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

16H3

The same clone is also sold as:

Santa Cruz Biotechnology: sc-57954

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig s5a	Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, et al. CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor. Nat Commun. 2017;8:7 pubmed publisher
western blot; human; 1:1000	Pinto A, Malacrida B, Oieni J, Serafini M, Davin A, Galbiati V, et al. DHEA modulates the effect of cortisol on RACK1 expression via interference with the splicing of the glucocorticoid receptor. Br J Pharmacol. 2015;172:2918-27 pubmed publisher
	Patel R, Carter G, Cooper D, Apostolatos H, Patel N. Transformer 2β homolog (Drosophila) (TRA2B) regulates protein kinase C δI (PKCδI) splice variant expression during 3T3L1 preadipocyte cell cycle. J Biol Chem. 2014;289:31662-72 pubmed publisher
	Amor S, Strassheim S, Dambrine G, Remy S, Rasschaert D, Laurent S. ICP27 protein of Marek's disease virus interacts with SR proteins and inhibits the splicing of cellular telomerase chTERT and viral vIL8 transcripts. J Gen Virol. 2011;92:1273-8 pubmed publisher
	Toiber D, Azkona G, Ben Ari S, Toran N, Soreq H, Dierssen M. Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiol Dis. 2010;40:348-59 pubmed publisher

product information

Catalog Number :

MABE126

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-SR protein family Antibody, clone 16H3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13247

Host Name :

Mouse

Antigen :

SR protein family

Clone :

16H3

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-SR protein family Antibody, clone 16H3

Cross Reactivity :

Human;Mouse;Rat

Background :

Ser-Arg-rich (SR) proteins make up a family of functionally and structurally conserved phosphoproteins, and are required components of alternative and constitutive pre-mRNA splicing. SR proteins are characterized by their modular composition consisting of two domains of interest: an N-terminal RNA recognition motif (RRM) which serves in the determination of DNA-binding specificity, and the RS domain, an arginine and serine rich, C-terminal domain that serves as a shuttling and localization director of SR proteins and as a splicing activation domain. They are involved in various aspects of pre-mRNA splicing and in spliceosome assembly including the identification and appropriation of splice-sites and the manipulation of alternative splicing regulation.

ALT Names :

splicing factor, arginine/serine-rich 6;arginine/serine-rich splicing factor 6;splicing factor, arginine/serine-rich, 55 kDa;Pre-mRNA-splicing factor SRP55;pre-mRNA splicing factor SRP55

Immunogen :

Dephosphorylated bovine SRp55 and GST-tagged recombinant dephosphorylated SRp55 (Neugebauer, KM et. al 1995).

Specificity :

This antibody recognizes the four nuclear proteins SRp75, SRp55, SRp40, and SRp20, plus ~20 other prominent nuclear proteins believed to correspond to the SR family.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt