SMARCA4 Antibody, clone 20C3.2 | EMD Millipore MABE121 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SMARCA4 Antibody, clone 20C3.2

catalog :

MABE121

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

20C3.2

reactivity :

human

application :

western blot, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:2000; fig 3	Pchelintsev N, Adams P, Nelson D. Critical Parameters for Efficient Sonication and Improved Chromatin Immunoprecipitation of High Molecular Weight Proteins. PLoS ONE. 2016;11:e0148023 pubmed publisher

product information

Catalog Number :

MABE121

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-SMARCA4 Antibody, clone 20C3.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P51532

Host Name :

Mouse

Antigen :

SMARCA4

Clone :

20C3.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-SMARCA4 Antibody, clone 20C3.2

Cross Reactivity :

Human;Rat

Background :

Also known as Protein BRG1 and SNF2-beta, among other aliases, SMARCA4 a transcriptional activator belonging to the SNF2/RAD54 helicase family, and acts as a component of the SWI/SNF ATP-dependent chromatin remodeling complexes family. BRG1 contains 4 domains of interest; a bromo domain, a helicase ATP-binding domain, a helicase C-terminal domain, and a HAS domain. It is a component of several different complexes with distinctive roles such as the CREST-BRG1 complex which regulates the activation of promoters in a calcium-dependent manner, releasing repressor complexes and recruiting activator complexes. It is also a part of the nBAF and npBAF complexes which are involved in the chromatin remodeling of mononucleosomes and nucleosomal arrays. As a component of the SWI/SNF complex, SMARCA4 has a role in tumor suppression and has been shown to regulate cell cycle and differentiation when present in neoplasma.

ALT Names :

Transcription activator BRG1;ATP-dependent helicase SMARCA4;BRG1-associated factor 190A;BAF190A;Mitotic growth and transcription activator;Protein BRG-1;Protein brahma homolog 1;SNF2-beta;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

Immunogen :

GST-tagged recombinant protein corresponding to the human SMARCA4.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt