LSD1 Antibody, clone 3D12 | EMD Millipore MABE114 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LSD1 Antibody, clone 3D12

catalog :

MABE114

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D12

The same clone is also sold as:

Abcam: ab90966

reactivity :

human

application :

western blot

product information

Catalog Number :

MABE114

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-LSD1 Antibody, clone 3D12

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O60341

Host Name :

Mouse

Antigen :

LSD1

Clone :

3D12

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-LSD1 Antibody, clone 3D12

Cross Reactivity :

Human

Background :

LSD1 (lysine specific demethylase 1), also known as BHC110, and KDM1, is a histone demethylase that specifically demethylates Lys4 of histone H3. Methylation of Histone H3 Lys4 is a specific tag for epigenetic transcriptional activation, suggesting a role for LSD1 as a corepressor. LSD1 plays a role in a number of chromatin-remodeling pathways and has been linked to pathological processes, such as tumorigenesis. LSD1 acts by oxidizing the substrate FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted Lys4 of histone H3, and may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 Lys4 on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. LSD1 may also demethylate Lys9 of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.

ALT Names :

BRAF35-HDAC complex protein BHC110;FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit;Flavin-containing amine oxidase domain-containing protein 2;amine oxidase (flavin containing) domain 2;lysine (K)-specific demethylase 1;lysine-specific histone demethylase 1

Immunogen :

Full length recombinant protein corresponding to human LSD1.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt