Brn-2 (POU3F2) Antibody, clone 8C4.2 | EMD Millipore MABD51 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Brn-2 (POU3F2) Antibody, clone 8C4.2

catalog :

MABD51

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8C4.2

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; human; 1:500; loading ...; fig s116c	Trevino A, Sinnott Armstrong N, Andersen J, Yoon S, Huber N, Pritchard J, et al. Chromatin accessibility dynamics in a model of human forebrain development. Science. 2020;367: pubmed publisher
western blot; human	Ishii J, Sato H, Yazawa T, Shishido Hara Y, Hiramatsu C, Nakatani Y, et al. Class III/IV POU transcription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation. Pathol Int. 2014;64:415-22 pubmed publisher

product information

Catalog Number :

MABD51

Subcategory :

Stem Cell Research

Product Name :

Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P20265

Host Name :

Mouse

Antigen :

Brn-2 (POU3F2)

Clone :

8C4.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2

Cross Reactivity :

Human;Rat

Background :

Brn-2 (POU domain, class 3, transcription factor 2; Oct-7; N-Oct-3; or POU3F2) is a member of a large family of POU-domain transcription factors. The highly homologous POU domain contains a POU-specific domain at the N-terminus, a POU-homeo domain at the C-terminus and an interconnecting linker region. The POU domain binds to the DNA sequence 5’-ATGCAAAT-3’. Brn-2 is highly expressed in the developing CNS and may play a role in neurogenesis, particularly in the development of the hypothalamus. Previous studies have also suggested that Brn-2 integrates signals downstream of the BRAF/MAP kinase and Wnt/β-catenin pathways, and Brn-2 may be involved in the transformation and proliferation of melanomas.

ALT Names :

POU domain, class 3, transcription factor 2;Brain-specific homeobox/POU domain protein 2;Brain-2;Brn-2;Nervous system-specific octamer-binding transcription factor N-Oct-3;Octamer-binding protein 7;Oct-7;Octamer-binding transcription factor 7;OTF-7

Immunogen :

GST-tagged recombinant protein corresponding human Brn-2 (POU3F2).

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt