AFP Antibody, clone 6E6 | EMD Millipore MABD170 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

AFP Antibody, clone 6E6

catalog :

MABD170

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6E6

The same clone is also sold as:

LifeSpan Biosciences: LS-B3881

reactivity :

human

application :

western blot

product information

Catalog Number :

MABD170

Subcategory :

Stem Cell Research

Product Name :

Anti-AFP Antibody, clone 6E6

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Host Name :

Mouse

Antigen :

AFP

Clone :

6E6

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-AFP Antibody, clone 6E6

Cross Reactivity :

Human

Background :

Alpha fetoprotein (AFP) or alternatively known as Alpha-1-fetoprotein or Alpha-fetoglobulin is encoded by the human gene named AFP/HPAFP is an important early fetal blood protein. It is a secreted protein found in the plasma of fetuses older than 4 weeks of age and reaches the highest levels at 12th-16th week of gestation and then drops to trace amounts after birth. It is produced by the fetal liver and yolk sac normally. In normal adults the level is very low, but AFP can be a marker associated with various cancers and in particular with liver cancer and hepatomas. Its function during development is thought to be similar to that of serum albumin binding various ions and fatty acids as well as bilirubin, but while AFP is the most abundant protein found in the human fetus its complete function is still largely unknown. AFP as a biomarker in infants is associated with various diseases, however, because AFP levels change normally over a wide range in the developing fetus accurate aging is essential. High levels of AFP may suggest that the developing baby has a neural tube defect such as spina bifida or anencephaly. High levels of AFP may also suggest defects with the esophagus or a failure of baby’s abdomen to close. Low levels of AFP and abnormal levels of hCG and estriol may indicate that the developing baby has Trisomy 21 (Down syndrome), Trisomy 18 (Edwards Syndrome) or another type of chromosome abnormality. EMD-Millipore’s Anti-AFP mouse monoclonal antibody has been tested in western blot on HepG2 and SMMC-7721 cell lysates.

ALT Names :

Alpha-fetoprotein;FETA;Alpha-1-fetoprotein;Alpha-fetoglobulin

Immunogen :

Purified recombinant fragment of human AFP expressed in E. Coli.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.