GATA Antibody3, clone 7B5 | EMD Millipore MABD117 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GATA Antibody3, clone 7B5

catalog :

MABD117

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7B5

The same clone is also sold as:

ProMab: 30050
MilliporeSigma: SAB5300458
LifeSpan Biosciences: LS-B4163
OriGene: AM06448SU-N
Invitrogen: MA5-15641
Novus Biologicals: NBP1-47397
Abnova: MAB10663

reactivity :

human

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABD117

Subcategory :

Stem Cell Research

Product Name :

Anti-GATA Antibody3, clone 7B5

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P23771

Host Name :

Mouse

Antigen :

GATA3

Clone :

7B5

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-GATA Antibody3, clone 7B5

Cross Reactivity :

Human

Background :

GATA-binding factor 3 (GATA3), also known as Trans-acting T-cell-specific transcription factor GATA-3, is a transcription factor containing a zinc finger domain. GATA3 is primarily expressed in T cells, where it thought to participate in T-cell receptor gene activation through binding to enhancers. Analysis of conditional GATA3 knockout mice confirmed the critical role of GATA3 in helper T cell differentiation and proliferation. Cells expressing GATA3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. Binding of GATA3 in the regulatory regions of the genes of these cytokines alters chromatin structure, increasing accessibility to other transcription factors. T cell receptor activation activates NFAT and other transcription factors that cooperate with GATA3 in inducing Th2 cell differentiation. Blocking GATA3 action has been suggested as a therapeutic strategy to treat asthma. GATA3 has also been implicated in developmental processes such as the development of the inner ear.

ALT Names :

Trans-acting T-cell-specific transcription factor GATA-3;GATA-binding factor 3

Immunogen :

Purified recombinant fragment of human GATA3 expressed in E. Coli.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.