uPAR Antibody, clone 2G10 (Azide Free) | EMD Millipore MABC88 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

uPAR Antibody, clone 2G10 (Azide Free)

catalog :

MABC88

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

2G10

reactivity :

human

application :

western blot, flow cytometry

product information

Catalog Number :

MABC88

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-uPAR Antibody, clone 2G10 (Azide Free)

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q03405

Host Name :

Rabbit

Antigen :

PLAUR

Clone :

2G10

Conjugate :

Purified

Purification Method :

Protein A purified

Isotype :

IgGκ

Product Description :

Anti-uPAR Antibody, clone 2G10 (Azide Free)

Cross Reactivity :

Human

Background :

UPAR protein or CD87 acts as the receptor for urokinase plasminogen activator (uPA), or urokinase, an important enzyme commonly found in the blood and extracellular matrix fluids. UPA is the enzyme that is responsible for the activation of plasmin, a powerful serine proteinase necessary for clotting, wound healing, and extracellular matrix degradation and remodeling. Urokinase also has major roles in vascular disease and cancer growth and spreading. UPAR, the receptor, is also important in cancer biology as it is through this receptor that the uPA effects are mediated, and these effects play a role in cell adhesion, migration and cell proliferation of cancers. UPAR also binds vitronectin and uPAR associated proteins (uPARAP) as well as several members of the integrin family of proteins. UPAR’s primary physiological role is as part of the uPA activation system which is involved in tissue reorganization and wound healing. By binding urokinase it restricts the activation of plasminogen to plasmin to the immediate vicinity of the cell membrane and thus helps to regulate and limit the strength and duration of the remodeling process.

ALT Names :

Urokinase plasminogen activator surface receptor, U-PAR, uPAR, Monocyte activation antigen Mo3, CD87

Immunogen :

Linear peptide corresponding to Human uPAR.

Package Size :

100 µL

Uses :

Western Blotting, Flow Cytometry, Inhibits Activity/Function

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.