CD148/DEP-1 Antibody, clone Ab1 (Azide Free) | EMD Millipore MABC87 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD148/DEP-1 Antibody, clone Ab1 (Azide Free)

catalog :

MABC87

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Ab 1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

product information

Catalog Number :

MABC87

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-CD148/DEP-1 Antibody, clone Ab1 (Azide Free)

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q12913

Host Name :

Mouse

Antigen :

PTPRJ

Clone :

Ab 1

Conjugate :

Purified

Purification Method :

Protein A purified

Isotype :

IgG1κ

Product Description :

Anti-CD148/DEP-1 Antibody, clone Ab1 (Azide Free)

Cross Reactivity :

Human, Mouse

Background :

CD148, also known as Density-enhanced phosphatase 1 (DEP-1), is a membrane bound phosphatase that dephosphorylates a large number of protein targets and kinases thus serving as a regulator of many signaling cascades. CD148/DEP-1 plays a role in cell adhesion, migration, proliferation and differentiation. CD148/DEP-1 also plays a role in macrophage migration, adhesion and spreading. CD148/DEP-1 is also central to T-cell receptor signaling and acts as a negative regulator. CD148/DEP-1 acts as a positive regulator of endothelial cell survival and enhances the barrier function of epithelial junctions during reassembly. CD148/DEP-1 is also a key regulator of platelet activation and thrombosis as well as a tumor suppressor. CD148/DEP-1 is localized at the cell membrane particularly at cell projections, ruffle membranes, and cell junctions and it is expressed in lymphocytes and epithelial cells and expression increases as cell density increases.

ALT Names :

CD148, DEP-1, Receptor-type tyrosine-protein phosphatase eta, Protein-tyrosine phosphatase eta, R-PTP-eta, Density-enhanced phosphatase 1, DEP1, HPTP eta, Protein-tyrosine phosphatase receptor type J, R-PTP-J

Immunogen :

His-tagged recombinant protein corresponding to Human CD148/DEP-1.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry (Paraffin), Inhibition, Immunoprecipitation

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.